ID   Y1842_MYCTO             Reviewed;         455 AA.
AC   P9WFP2; L0T820; P95166; Q50592;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 42.
DE   RecName: Full=UPF0053 protein MT1890;
GN   OrderedLocusNames=MT1890;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the UPF0053 family. {ECO:0000305}.
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DR   EMBL; AE000516; AAK46161.1; -; Genomic_DNA.
DR   PIR; B70664; B70664.
DR   RefSeq; WP_003917539.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WFP2; -.
DR   SMR; P9WFP2; -.
DR   EnsemblBacteria; AAK46161; AAK46161; MT1890.
DR   KEGG; mtc:MT1890; -.
DR   PATRIC; fig|83331.31.peg.2034; -.
DR   HOGENOM; CLU_015237_4_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR   CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR   Gene3D; 3.10.580.10; -; 1.
DR   Gene3D; 3.30.465.10; -; 1.
DR   InterPro; IPR000644; CBS_dom.
DR   InterPro; IPR046342; CBS_dom_sf.
DR   InterPro; IPR002550; CNNM.
DR   InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR   InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR   InterPro; IPR044751; Ion_transp-like_CBS.
DR   InterPro; IPR005170; Transptr-assoc_dom.
DR   Pfam; PF00571; CBS; 2.
DR   Pfam; PF03471; CorC_HlyC; 1.
DR   Pfam; PF01595; DUF21; 1.
DR   SMART; SM01091; CorC_HlyC; 1.
DR   SUPFAM; SSF54631; SSF54631; 1.
DR   SUPFAM; SSF56176; SSF56176; 1.
DR   PROSITE; PS51371; CBS; 2.
DR   PROSITE; PS51846; CNNM; 1.
PE   3: Inferred from homology;
KW   CBS domain; Cell membrane; Membrane; Repeat; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..455
FT                   /note="UPF0053 protein MT1890"
FT                   /id="PRO_0000428504"
FT   TRANSMEM        6..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        68..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        106..126
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        148..168
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          2..205
FT                   /note="CNNM transmembrane"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01193"
FT   DOMAIN          224..285
FT                   /note="CBS 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT   DOMAIN          286..346
FT                   /note="CBS 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
SQ   SEQUENCE   455 AA;  48154 MW;  49F6BEC2B50B3B0C CRC64;
     MNLTDTVATI LAILALTAGT GVFVAAEFSL TALDRSTVEA NARGGTSRDR FIQRAHHRLS
     FQLSGAQLGI SITTLATGYL TEPLVAELPH PGLVAVGMSD RVADGLITFF ALVIVTSLSM
     VFGELVPKYL AVARPLRTAR SVVAGQVLFS LLLTPAIRLT NGAANWIVRR LGIEPAEELR
     SARTPQELVS LVRSSARSGA LDDATAWLMR RSLQFGALTA EELMTPRSKI VALQTDDTIA
     DLVAAAAASG FSRFPVVEGD LDATVGIVHV KQVFEVPPGD RAHTLLTTVA EPVAVVPSTL
     DGDAVMAQVR ASALQTAMVV DEYGGTAGMV TLEDLIEEIV GDVRDEHDDA TPDVVAAGNG
     WRVSGLLRID EVASATGYRA PDGPYETISG LVLRELGHIP VAGETVELTA LDQDGLPDDS
     MRWLATVIQM DGRRIDLLEL IKMGGHADPG SGRGR