ID   Y1842_MYCTU             Reviewed;         455 AA.
AC   P9WFP3; L0T820; P95166; Q50592;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 41.
DE   RecName: Full=UPF0053 protein Rv1842c;
GN   OrderedLocusNames=Rv1842c; ORFNames=MTCY1A11.02, MTCY359.31;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the UPF0053 family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP44608.1; -; Genomic_DNA.
DR   PIR; B70664; B70664.
DR   RefSeq; NP_216358.1; NC_000962.3.
DR   RefSeq; WP_003899046.1; NZ_NVQJ01000013.1.
DR   AlphaFoldDB; P9WFP3; -.
DR   SMR; P9WFP3; -.
DR   STRING; 83332.Rv1842c; -.
DR   PaxDb; P9WFP3; -.
DR   DNASU; 885739; -.
DR   GeneID; 885739; -.
DR   KEGG; mtu:Rv1842c; -.
DR   TubercuList; Rv1842c; -.
DR   eggNOG; COG1253; Bacteria.
DR   OMA; EHTMVRN; -.
DR   PhylomeDB; P9WFP3; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR   CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR   Gene3D; 3.10.580.10; -; 1.
DR   Gene3D; 3.30.465.10; -; 1.
DR   InterPro; IPR000644; CBS_dom.
DR   InterPro; IPR046342; CBS_dom_sf.
DR   InterPro; IPR002550; CNNM.
DR   InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR   InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR   InterPro; IPR044751; Ion_transp-like_CBS.
DR   InterPro; IPR005170; Transptr-assoc_dom.
DR   Pfam; PF00571; CBS; 2.
DR   Pfam; PF03471; CorC_HlyC; 1.
DR   Pfam; PF01595; DUF21; 1.
DR   SMART; SM01091; CorC_HlyC; 1.
DR   SUPFAM; SSF54631; SSF54631; 1.
DR   SUPFAM; SSF56176; SSF56176; 1.
DR   PROSITE; PS51371; CBS; 2.
DR   PROSITE; PS51846; CNNM; 1.
PE   1: Evidence at protein level;
KW   CBS domain; Cell membrane; Membrane; Reference proteome; Repeat;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..455
FT                   /note="UPF0053 protein Rv1842c"
FT                   /id="PRO_0000088380"
FT   TRANSMEM        6..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        68..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        106..126
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        148..168
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          2..205
FT                   /note="CNNM transmembrane"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01193"
FT   DOMAIN          224..285
FT                   /note="CBS 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT   DOMAIN          286..346
FT                   /note="CBS 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
SQ   SEQUENCE   455 AA;  48124 MW;  49F6A31F7516E6CC CRC64;
     MNLTDTVATI LAILALTAGT GVFVAAEFSL TALDRSTVEA NARGGTSRDR FIQRAHHRLS
     FQLSGAQLGI SITTLATGYL TEPLVAELPH PGLVAVGMSD RVADGLITFF ALVIVTSLSM
     VFGELVPKYL AVARPLRTAR SVVAGQVLFS LLLTPAIRLT NGAANWIVRR LGIEPAEELR
     SARTPQELVS LVRSSARSGA LDDATAWLMR RSLQFGALTA EELMTPRSKI VALQTDDTIA
     DLVAAAAASG FSRFPVVEGD LDATVGIVHV KQVFEVPPGD RAHTLLTTVA EPVAVVPSTL
     DGDAVMAQVR ASALQTAMVV DEYGGTAGMV TLEDLIEEIV GDVRDEHDDA TPDVVAAGNG
     WRVSGLLRID EVASATGYRA PDGPYETIGG LVLRELGHIP VAGETVELTA LDQDGLPDDS
     MRWLATVIQM DGRRIDLLEL IKMGGHADPG SGRGR