ID   Y1846_MYCBO             Reviewed;         234 AA.
AC   P67439; A0A1R3XZF0; Q50617; X2BJA0;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Uncharacterized HTH-type transcriptional regulator Mb1846;
GN   OrderedLocusNames=BQ2027_MB1846;
OS   Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=233413;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA   Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA   Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA   Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA   Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT   "The complete genome sequence of Mycobacterium bovis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA   Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA   Robbe-Austerman S., Gordon S.V.;
RT   "Updated reference genome sequence and annotation of Mycobacterium bovis
RT   AF2122/97.";
RL   Genome Announc. 5:E00157-E00157(2017).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; LT708304; SIU00450.1; -; Genomic_DNA.
DR   RefSeq; NP_855498.1; NC_002945.3.
DR   RefSeq; WP_003409205.1; NC_002945.4.
DR   AlphaFoldDB; P67439; -.
DR   SMR; P67439; -.
DR   EnsemblBacteria; SIU00450; SIU00450; BQ2027_MB1846.
DR   GeneID; 45425791; -.
DR   PATRIC; fig|233413.5.peg.2027; -.
DR   OMA; AKCFLLW; -.
DR   Proteomes; UP000001419; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProt.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001647; HTH_TetR.
DR   InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR   InterPro; IPR025996; TetR_C_WHG.
DR   Pfam; PF13305; TetR_C_33; 1.
DR   Pfam; PF00440; TetR_N; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF48498; SSF48498; 1.
DR   PROSITE; PS50977; HTH_TETR_2; 1.
PE   4: Predicted;
KW   DNA-binding; Membrane; Transcription; Transcription regulation;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..234
FT                   /note="Uncharacterized HTH-type transcriptional regulator
FT                   Mb1846"
FT                   /id="PRO_0000070665"
FT   TRANSMEM        190..210
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          15..75
FT                   /note="HTH tetR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
SQ   SEQUENCE   234 AA;  25353 MW;  E67840A7C7B671C8 CRC64;
     MCQTCRVGKR RDAREQIEAK IVELGRRQLL DHGAAGLSLR AIARNLGMVS SAVYRYVSSR
     DELLTLLLVD AYSDLADTVD RARDDTVADS WSDDVIAIAR AVRGWAVTNP ARWALLYGSP
     VPGYHAPPDR TAGVATRVVG AFFDAIAAGI ATGDIRLTDD VAPQPMSSDF EKIRQEFGFP
     GDDRVVTKCF LLWAGVVGAI SLEVFGQYGA DMLTDPGVVF DAQTRLLVAV LAEH