ID   Y1846_STAAM             Reviewed;         374 AA.
AC   Q99T32;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=UPF0754 membrane protein SAV1846;
GN   OrderedLocusNames=SAV1846;
OS   Staphylococcus aureus (strain Mu50 / ATCC 700699).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=158878;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Mu50 / ATCC 700699;
RX   PubMed=11418146; DOI=10.1016/s0140-6736(00)04403-2;
RA   Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L.,
RA   Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA   Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA   Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H.,
RA   Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K.,
RA   Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H.,
RA   Hiramatsu K.;
RT   "Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
RL   Lancet 357:1225-1240(2001).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UPF0754 family. {ECO:0000305}.
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DR   EMBL; BA000017; BAB58008.1; -; Genomic_DNA.
DR   RefSeq; WP_000992518.1; NC_002758.2.
DR   AlphaFoldDB; Q99T32; -.
DR   PaxDb; Q99T32; -.
DR   EnsemblBacteria; BAB58008; BAB58008; SAV1846.
DR   KEGG; sav:SAV1846; -.
DR   HOGENOM; CLU_042384_0_0_9; -.
DR   OMA; DTIMGSL; -.
DR   PhylomeDB; Q99T32; -.
DR   BioCyc; SAUR158878:SAV_RS09960-MON; -.
DR   Proteomes; UP000002481; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR007383; DUF445.
DR   InterPro; IPR016991; UCP032178.
DR   Pfam; PF04286; DUF445; 1.
DR   PIRSF; PIRSF032178; UCP032178; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..374
FT                   /note="UPF0754 membrane protein SAV1846"
FT                   /id="PRO_0000388311"
FT   TRANSMEM        4..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        354..374
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   374 AA;  42706 MW;  35AC8B78353A622D CRC64;
     MNALFIIIFM IVVGAIIGGI TNVIAIRMLF HPFKPYYIFK FRVPFTPGLI PKRREEIATK
     IGQVIEEHLL TETLINEKLK SEQSQQAIES MIQQQLQKLT KDQLSIKQIT SQIDIDLEQV
     LQTNGNQYIE SQLNNYYTKH QNQTIASLLP NQLVTFLDQH VDNATDLLCD RARNYLSSAK
     GTQDINDMLD TFFHEKGKLI GMLQMFMTKE SIADRIQQEL IRLTSHPKAR TIVTSLITNE
     YQTFKDKPLN ELLDASQFNE IAENLSVYVT TYASNQANKP VVTLMPQFVD YLEGQLSSKL
     ANLIIEKLSI HLSTIMKKVD LRGLIEEQIN TFDLDYIEKL IIEIANKELK LIMSLGFILG
     GIIGFFQGLV AIFV