ID   Y1847_MYCTU             Reviewed;         140 AA.
AC   P9WIM3; L0T825; P95162;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 36.
DE   RecName: Full=Putative esterase Rv1847;
DE            EC=3.1.2.-;
GN   OrderedLocusNames=Rv1847; ORFNames=MTCY359.26c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION AS A DRUG TARGET [LARGE SCALE ANALYSIS].
RX   PubMed=19099550; DOI=10.1186/1752-0509-2-109;
RA   Raman K., Yeturu K., Chandra N.;
RT   "targetTB: a target identification pipeline for Mycobacterium tuberculosis
RT   through an interactome, reactome and genome-scale structural analysis.";
RL   BMC Syst. Biol. 2:109-109(2008).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- MISCELLANEOUS: Was identified as a high-confidence drug target.
CC   -!- SIMILARITY: Belongs to the thioesterase PaaI family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP44613.1; -; Genomic_DNA.
DR   PIR; G70664; G70664.
DR   RefSeq; NP_216363.1; NC_000962.3.
DR   RefSeq; WP_003899048.1; NZ_NVQJ01000013.1.
DR   PDB; 3S4K; X-ray; 1.70 A; A/B=1-140.
DR   PDBsum; 3S4K; -.
DR   AlphaFoldDB; P9WIM3; -.
DR   SMR; P9WIM3; -.
DR   STRING; 83332.Rv1847; -.
DR   PaxDb; P9WIM3; -.
DR   DNASU; 885734; -.
DR   GeneID; 885734; -.
DR   KEGG; mtu:Rv1847; -.
DR   TubercuList; Rv1847; -.
DR   eggNOG; COG2050; Bacteria.
DR   OMA; QHGGVYC; -.
DR   PhylomeDB; P9WIM3; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0061522; F:1,4-dihydroxy-2-naphthoyl-CoA thioesterase activity; IBA:GO_Central.
DR   InterPro; IPR029069; HotDog_dom_sf.
DR   InterPro; IPR003736; PAAI_dom.
DR   InterPro; IPR006683; Thioestr_dom.
DR   Pfam; PF03061; 4HBT; 1.
DR   SUPFAM; SSF54637; SSF54637; 1.
DR   TIGRFAMs; TIGR00369; unchar_dom_1; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Hydrolase; Reference proteome.
FT   CHAIN           1..140
FT                   /note="Putative esterase Rv1847"
FT                   /id="PRO_0000156683"
FT   HELIX           16..21
FT                   /evidence="ECO:0007829|PDB:3S4K"
FT   STRAND          24..29
FT                   /evidence="ECO:0007829|PDB:3S4K"
FT   STRAND          32..39
FT                   /evidence="ECO:0007829|PDB:3S4K"
FT   HELIX           41..43
FT                   /evidence="ECO:0007829|PDB:3S4K"
FT   STRAND          48..50
FT                   /evidence="ECO:0007829|PDB:3S4K"
FT   HELIX           52..71
FT                   /evidence="ECO:0007829|PDB:3S4K"
FT   STRAND          79..89
FT                   /evidence="ECO:0007829|PDB:3S4K"
FT   STRAND          95..107
FT                   /evidence="ECO:0007829|PDB:3S4K"
FT   STRAND          109..119
FT                   /evidence="ECO:0007829|PDB:3S4K"
FT   STRAND          125..136
FT                   /evidence="ECO:0007829|PDB:3S4K"
SQ   SEQUENCE   140 AA;  15098 MW;  6874C72A57095635 CRC64;
     MQPSPDSPAP LNVTVPFDSE LGLQFTELGP DGARAQLDVR PKLLQLTGVV HGGVYCAMIE
     SIASMAAFAW LNSHGEGGSV VGVNNNTDFV RSISSGMVYG TAEPLHRGRR QQLWLVTITD
     DTDRVVARGQ VRLQNLEARP