ID   Y1851_PYRFU             Reviewed;         315 AA.
AC   Q8TZX4;
DT   25-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 2.
DT   25-MAY-2022, entry version 106.
DE   RecName: Full=Putative HTH-type transcriptional regulatory protein PF1851 {ECO:0000255|HAMAP-Rule:MF_00584};
GN   OrderedLocusNames=PF1851;
OS   Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Pyrococcus.
OX   NCBI_TaxID=186497;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43587 / DSM 3638 / JCM 8422 / Vc1;
RX   PubMed=10430560; DOI=10.1093/genetics/152.4.1299;
RA   Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M.,
RA   DiRuggiero J., Robb F.T.;
RT   "Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P.
RT   horikoshii inferred from complete genomic sequences.";
RL   Genetics 152:1299-1305(1999).
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAL81975.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE009950; AAL81975.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_048059097.1; NZ_CP023154.1.
DR   AlphaFoldDB; Q8TZX4; -.
DR   SMR; Q8TZX4; -.
DR   STRING; 186497.PF1851; -.
DR   EnsemblBacteria; AAL81975; AAL81975; PF1851.
DR   GeneID; 41713671; -.
DR   KEGG; pfu:PF1851; -.
DR   PATRIC; fig|186497.12.peg.1922; -.
DR   eggNOG; arCOG04152; Archaea.
DR   HOGENOM; CLU_075726_0_0_2; -.
DR   OMA; PGVVYFR; -.
DR   OrthoDB; 76134at2157; -.
DR   PhylomeDB; Q8TZX4; -.
DR   Proteomes; UP000001013; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   CDD; cd00093; HTH_XRE; 1.
DR   Gene3D; 1.10.260.40; -; 1.
DR   HAMAP; MF_00584; HTH_type_cro_C1; 1.
DR   InterPro; IPR020886; Arc_TR_HTH.
DR   InterPro; IPR001387; Cro/C1-type_HTH.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   Pfam; PF01381; HTH_3; 1.
DR   SMART; SM00530; HTH_XRE; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   PROSITE; PS50943; HTH_CROC1; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..315
FT                   /note="Putative HTH-type transcriptional regulatory protein
FT                   PF1851"
FT                   /id="PRO_0000144862"
FT   DOMAIN          131..189
FT                   /note="HTH cro/C1-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00584"
FT   DNA_BIND        142..161
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00584"
SQ   SEQUENCE   315 AA;  35912 MW;  9EC36242FF628B0E CRC64;
     MDKEQLTTVV EKMLNSIGFK TARVSFRGGC FDLVATRQIL LLFIKTLVNI DKFTEEQAED
     LKRLAKLFRA SALLVGLRTK NIELEDGVVY ERFGIYAVNP ETLFSILAGT EYPLVMAERG
     GFFVRIDGER LRELREKYGY STTELAEMLG VSRKSVQRYE KGEGMVSIDV AIRLEEIFDE
     PLVKPIDIFK AKIEKVTLSS PPENELEKEV FDRLERLGMS VVKIKRAPFN AVTKEEDEEV
     NLLTGIDEKK TPSTIRRVRL VNQIAEFVES EGVFVLNEKK TEVVGKVPII PKDILNKVRD
     VDELMEIIKE LRSST