ID   Y1856_MYCTU             Reviewed;         223 AA.
AC   P9WGQ1; L0T7W6; P95158; Q7D7W5;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   02-NOV-2016, sequence version 2.
DT   03-AUG-2022, entry version 42.
DE   RecName: Full=Putative oxidoreductase Rv1856c;
DE            EC=1.-.-.-;
GN   OrderedLocusNames=Rv1856c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION AS A DRUG TARGET [LARGE SCALE ANALYSIS].
RX   PubMed=19099550; DOI=10.1186/1752-0509-2-109;
RA   Raman K., Yeturu K., Chandra N.;
RT   "targetTB: a target identification pipeline for Mycobacterium tuberculosis
RT   through an interactome, reactome and genome-scale structural analysis.";
RL   BMC Syst. Biol. 2:109-109(2008).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- MISCELLANEOUS: Was identified as a high-confidence drug target.
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CCP44622.1; Type=Erroneous initiation; Note=Extended N-terminus.;
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DR   EMBL; AL123456; CCP44622.1; ALT_INIT; Genomic_DNA.
DR   PIR; H70665; H70665.
DR   RefSeq; NP_216372.1; NC_000962.3.
DR   AlphaFoldDB; P9WGQ1; -.
DR   SMR; P9WGQ1; -.
DR   STRING; 83332.Rv1856c; -.
DR   PaxDb; P9WGQ1; -.
DR   DNASU; 885708; -.
DR   GeneID; 885708; -.
DR   KEGG; mtu:Rv1856c; -.
DR   TubercuList; Rv1856c; -.
DR   eggNOG; COG1028; Bacteria.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IBA:GO_Central.
DR   GO; GO:0030497; P:fatty acid elongation; IBA:GO_Central.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   1: Evidence at protein level;
KW   Oxidoreductase; Reference proteome.
FT   CHAIN           1..223
FT                   /note="Putative oxidoreductase Rv1856c"
FT                   /id="PRO_0000415509"
FT   BINDING         4..28
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         128
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   223 AA;  23058 MW;  2273A32B9DC292FA CRC64;
     MEVLVTGGDT DLGRTMAEGF RNDGHKVTLV GARRGDLEVA AKELDVDAVV CDTTDPTSLT
     EARGLFPRHL DTIVNVPAPS WDAGDPRAYS VSDTANAWRN ALDATVLSVV LTVQSVGDHL
     RSGGSIVSVV AENPPAGGAE SAIKAALSNW IAGQAAVFGT RGITINTVAC GRSVQTGYEG
     LSRTPAPVAA EIARLALFLT TPAARHITGQ TLHVSHGALA HFG