ID   Y1856_STRP3             Reviewed;         287 AA.
AC   P0DB50; P60948; Q99XH5;
DT   27-JUL-2011, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 1.
DT   25-MAY-2022, entry version 41.
DE   RecName: Full=Putative sugar uptake protein SpyM3_1856;
GN   OrderedLocusNames=SpyM3_1856;
OS   Streptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=198466;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-595 / MGAS315;
RX   PubMed=12122206; DOI=10.1073/pnas.152298499;
RA   Beres S.B., Sylva G.L., Barbian K.D., Lei B., Hoff J.S., Mammarella N.D.,
RA   Liu M.-Y., Smoot J.C., Porcella S.F., Parkins L.D., Campbell D.S.,
RA   Smith T.M., McCormick J.K., Leung D.Y.M., Schlievert P.M., Musser J.M.;
RT   "Genome sequence of a serotype M3 strain of group A Streptococcus: phage-
RT   encoded toxins, the high-virulence phenotype, and clone emergence.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:10078-10083(2002).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the GRP transporter (TC 2.A.7.5) family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAM80463.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE014074; AAM80463.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_002992310.1; NC_004070.1.
DR   AlphaFoldDB; P0DB50; -.
DR   SMR; P0DB50; -.
DR   EnsemblBacteria; AAM80463; AAM80463; SpyM3_1856.
DR   GeneID; 57853534; -.
DR   KEGG; spg:SpyM3_1856; -.
DR   HOGENOM; CLU_076024_0_0_9; -.
DR   OMA; VNTKMGG; -.
DR   Proteomes; UP000000564; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015144; F:carbohydrate transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR010651; Sugar_transport.
DR   PANTHER; PTHR16119; PTHR16119; 2.
DR   Pfam; PF06800; Sugar_transport; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Sugar transport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..287
FT                   /note="Putative sugar uptake protein SpyM3_1856"
FT                   /id="PRO_0000213664"
FT   TRANSMEM        4..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        33..50
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        55..72
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        85..107
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        117..134
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        154..171
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        181..200
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        207..229
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        234..256
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        268..285
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   287 AA;  31222 MW;  3C62440F18F7E5A2 CRC64;
     MEGIFYALIP MFTWGSIGFV SNKIGGKPSQ QTLGMTFGAL LFSLAVWLIV RPEMTLQLWL
     FGILGGFIWS IGQTGQFHAM QYMGVSVANP LSSGSQLVLG SLIGVLVFHE WTRPMQFVVG
     SLALLLLIVG FYFSSKQDDA NAQVNHLHNF SKGFRALTYS TIGYVMYAVL FNNIMKFEVL
     SVILPMAVGM VLGAITFMSF KISIDQYVIK NSVVGLLWGI GNIFMLLAAS KAGLAIAFSF
     SQLGAIISIV GGILFLGETK TKKEMRWVVT GIICFIVGAI LLGVVKS