ID   Y1859_MYCBO             Reviewed;         247 AA.
AC   P67670; A0A1R3XZE8; Q50605; X2BJ64;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=Uncharacterized HTH-type transcriptional regulator Mb1859;
GN   OrderedLocusNames=BQ2027_MB1859;
OS   Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=233413;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA   Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA   Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA   Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA   Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT   "The complete genome sequence of Mycobacterium bovis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA   Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA   Robbe-Austerman S., Gordon S.V.;
RT   "Updated reference genome sequence and annotation of Mycobacterium bovis
RT   AF2122/97.";
RL   Genome Announc. 5:E00157-E00157(2017).
CC   -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:P9WME7}.
CC   -!- DOMAIN: Contains an N-terminal DNA-binding domain, a linker region and
CC       a C-terminal effector binding domain. Dimerization is mediated via the
CC       C-terminal domain. {ECO:0000250|UniProtKB:P9WME7}.
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DR   EMBL; LT708304; SIU00463.1; -; Genomic_DNA.
DR   RefSeq; NP_855511.1; NC_002945.3.
DR   RefSeq; WP_003409239.1; NC_002945.4.
DR   AlphaFoldDB; P67670; -.
DR   SMR; P67670; -.
DR   EnsemblBacteria; SIU00463; SIU00463; BQ2027_MB1859.
DR   GeneID; 45425802; -.
DR   PATRIC; fig|233413.5.peg.2039; -.
DR   OMA; NPQTRAH; -.
DR   Proteomes; UP000001419; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR009061; DNA-bd_dom_put_sf.
DR   InterPro; IPR000551; MerR-type_HTH_dom.
DR   Pfam; PF00376; MerR; 1.
DR   SMART; SM00422; HTH_MERR; 1.
DR   SUPFAM; SSF46955; SSF46955; 1.
DR   PROSITE; PS50937; HTH_MERR_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Transcription; Transcription regulation.
FT   CHAIN           1..247
FT                   /note="Uncharacterized HTH-type transcriptional regulator
FT                   Mb1859"
FT                   /id="PRO_0000098169"
FT   DOMAIN          11..85
FT                   /note="HTH merR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00254"
FT   DNA_BIND        14..38
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00254"
SQ   SEQUENCE   247 AA;  26443 MW;  C3BA9AE7E08B3D37 CRC64;
     MSAPDSPALA GMSIGAVLDL LRPDFPDVTI SKIRFLEAEG LVTPRRASSG YRRFTAYDCA
     RLRFILTAQR DHYLPLKVIR AQLDAQPDGE LPPFGSPYVL PRLVPVAGDS AGGVGSDTAS
     VSLTGIRLSR EDLLERSEVA DELLTALLKA GVITTGPGGF FDEHAVVILQ CARALAEYGV
     EPRHLRAFRS AADRQSDLIA QIAGPLVKAG KAGARDRADD LAREVAALAI TLHTSLIKSA
     VRDVLHR