Y1866_MYCBO
ID Y1866_MYCBO Reviewed; 628 AA.
AC P0A5F6; A0A1R3XZG7; Q50598; X2BJC0;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2005, sequence version 1.
DT 25-MAY-2022, entry version 87.
DE RecName: Full=Putative serine esterase Mb1866c;
DE EC=3.1.1.-;
GN OrderedLocusNames=BQ2027_MB1866C;
OS Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=233413;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-935 / AF2122/97;
RX PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT "The complete genome sequence of Mycobacterium bovis.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=ATCC BAA-935 / AF2122/97;
RX PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA Robbe-Austerman S., Gordon S.V.;
RT "Updated reference genome sequence and annotation of Mycobacterium bovis
RT AF2122/97.";
RL Genome Announc. 5:E00157-E00157(2017).
CC -!- SIMILARITY: Belongs to the CocE/NonD hydrolase family. {ECO:0000305}.
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DR EMBL; LT708304; SIU00470.1; -; Genomic_DNA.
DR RefSeq; NP_855518.1; NC_002945.3.
DR RefSeq; WP_003409258.1; NC_002945.4.
DR AlphaFoldDB; P0A5F6; -.
DR SMR; P0A5F6; -.
DR PRIDE; P0A5F6; -.
DR EnsemblBacteria; SIU00470; SIU00470; BQ2027_MB1866C.
DR PATRIC; fig|233413.5.peg.2046; -.
DR OMA; AHNRWKE; -.
DR Proteomes; UP000001419; Chromosome.
DR GO; GO:0052689; F:carboxylic ester hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0008239; F:dipeptidyl-peptidase activity; IEA:InterPro.
DR Gene3D; 3.40.50.1820; -; 2.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR005674; CocE/Ser_esterase.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR000383; Xaa-Pro-like_dom.
DR InterPro; IPR013736; Xaa-Pro_dipept_C.
DR Pfam; PF02129; Peptidase_S15; 1.
DR Pfam; PF08530; PepX_C; 1.
DR SMART; SM00939; PepX_C; 1.
DR SUPFAM; SSF49785; SSF49785; 1.
DR SUPFAM; SSF53474; SSF53474; 1.
DR TIGRFAMs; TIGR00976; NonD; 1.
PE 3: Inferred from homology;
KW Hydrolase; Serine esterase.
FT CHAIN 1..628
FT /note="Putative serine esterase Mb1866c"
FT /id="PRO_0000103909"
FT ACT_SITE 156
FT /note="Acyl-ester intermediate"
FT /evidence="ECO:0000250"
FT ACT_SITE 322
FT /note="Charge relay system"
FT /evidence="ECO:0000250"
FT ACT_SITE 350
FT /note="Charge relay system"
FT /evidence="ECO:0000250"
SQ SEQUENCE 628 AA; 69932 MW; C03FCA57776DEDCF CRC64;
MTRRGGSDAA WYSAPDQRSA YPRYRGMRYS SCYVTMRDGV RIAIDLYLPA GLTSAARLPA
ILHQTRYYRS LQLRWPLRML LGGKPLQHIA ADKRRRRRFV ASGYAWVDVD VRGSGASFGA
RVCEWSSDEI RDGAEIVDWI VRQPWCNGTV AALGNSYDGT SAELLLVNQH PAVRVIAPCF
SLFDVYTDIA FPGGIHAAWF TDTWGRYNEA LDRNALHEVV GWWAKLPVTG MQPVQEDRDR
SLRDGAIAAH RGNYDVHQIA GSLTFRDDVS ASDPYRGQPD ARLEPIGTPI ESGSINLISP
HNYWRDVQAS GAAIYSYSGW FDGGYAHAAI KRFLTVSTPG SHLILGPWNH TGGWRVDPLR
GLSRPDFDHD GELLRFIDHH VKGADTGIGS EPPVHYFTMV ENRWKSADTW PPPATTQSYY
LSADRQLRPD APDCDSGADE YVVDQTAGTG ERSRWRSQVG IGGHVCYPDR KAQDAKLLTY
TSAPLDHPLE VTGHVVVTLF ITSTSSDGTF FVYLEDVDPR GRVAYITEGQ LRAIHRRLSD
GPPPYRQVVP YRTFASGDAW PLVPGEIARL TFDLLPTSYL FQPGHRIRIA IAGADASHFA
ILPGCAPTVR VYRSRMHASR IDLPVIQP
