Y1866_MYCTU
ID Y1866_MYCTU Reviewed; 792 AA.
AC P95149; I6YBT6; L0T7X6;
DT 01-APR-2015, integrated into UniProtKB/Swiss-Prot.
DT 25-MAY-2022, sequence version 3.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Probable CoA-transferase Rv1866 {ECO:0000305};
DE EC=2.8.3.- {ECO:0000305};
GN OrderedLocusNames=Rv1866 {ECO:0000312|EMBL:CCP44632.1},
GN RVBD_1866 {ECO:0000312|EMBL:AFN49795.1};
GN ORFNames=P425_01930 {ECO:0000312|EMBL:KBJ34099.1};
OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83332;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT genome sequence.";
RL Nature 393:537-544(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RG The Broad Institute Genome Sequencing Platform;
RA Galagan J., Kreiswirth B., Dobos K., Fortune S., Fitzgerald M., Young S.K.,
RA Zeng Q., Gargeya S., Abouelleil A., Alvarado L., Berlin A.M., Chapman S.B.,
RA Gainer-Dewar J., Goldberg J., Gnerre S., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Larimer J., McCowan C., Murphy C., Pearson M.,
RA Poon T., Priest M., Roberts A., Saif S., Shea T., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The genome sequence of Mycobacterium tuberculosis H37Rv.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RG The Broad Institute Genomics Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Earl A.M., Kreiswirth B., Gomez J., Victor T., Desjardins C., Abeel T.,
RA Young S., Zeng Q., Gargeya S., Abouelleil A., Alvarado L., Chapman S.B.,
RA Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C.,
RA Imamovic A., Larimer J., Murphy C., Naylor J., Pearson M., Poon T.W.,
RA Priest M., Roberts A., Saif S., Shea T., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The genome sequence of Mycobacterium tuberculosis H37Rv.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP PROTEIN SEQUENCE OF 1-18, AND SEQUENCE REVISION TO N-TERMINUS.
RC STRAIN=H37Rv;
RX PubMed=34915127; DOI=10.1016/j.ygeno.2021.12.001;
RA Shi J., Meng S., Wan L., Zhang Z., Jiang S., Zhu H., Dai E., Chang L.,
RA Gao H., Wan K., Zhang L., Zhao X., Liu H., Lyu Z., Zhang Y., Xu P.;
RT "Deep N-terminomics of Mycobacterium tuberculosis H37Rv extensively correct
RT annotated encoding genes.";
RL Genomics 114:292-304(2022).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT mass spectrometry.";
RL Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC -!- FUNCTION: Probable CoA-transferase. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the CoA-transferase III family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AFN49795.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000269|PubMed:34915127};
CC Sequence=CCP44632.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000269|PubMed:34915127};
CC Sequence=KBJ34099.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000269|PubMed:34915127};
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DR EMBL; AL123456; CCP44632.1; ALT_INIT; Genomic_DNA.
DR EMBL; CP003248; AFN49795.1; ALT_INIT; Genomic_DNA.
DR EMBL; JLDD01000021; KBJ34099.1; ALT_INIT; Genomic_DNA.
DR RefSeq; NP_216382.3; NC_000962.3.
DR AlphaFoldDB; P95149; -.
DR SMR; P95149; -.
DR STRING; 83332.Rv1866; -.
DR PaxDb; P95149; -.
DR PRIDE; P95149; -.
DR GeneID; 885733; -.
DR KEGG; mtu:Rv1866; -.
DR KEGG; mtv:RVBD_1866; -.
DR PATRIC; fig|83332.111.peg.2074; -.
DR TubercuList; Rv1866; -.
DR eggNOG; COG1804; Bacteria.
DR Proteomes; UP000001584; Chromosome.
DR GO; GO:0009274; C:peptidoglycan-based cell wall; HDA:MTBBASE.
DR GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.30.1540.10; -; 2.
DR Gene3D; 3.40.50.10540; -; 2.
DR InterPro; IPR003673; CoA-Trfase_fam_III.
DR InterPro; IPR044855; CoA-Trfase_III_dom3_sf.
DR InterPro; IPR023606; CoA-Trfase_III_dom_1_sf.
DR Pfam; PF02515; CoA_transf_3; 2.
DR SUPFAM; SSF89796; SSF89796; 2.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Reference proteome; Transferase.
FT CHAIN 1..792
FT /note="Probable CoA-transferase Rv1866"
FT /id="PRO_0000432516"
FT ACT_SITE 558
FT /note="Nucleophile"
FT /evidence="ECO:0000250|UniProtKB:P69902"
SQ SEQUENCE 792 AA; 84506 MW; 93F534E978AED4E7 CRC64;
MLDLSDGCSA GGTDMVTRLL ADLGADVLKV EPPGGSPGRH VRPTLAGTSI GFAMHNANKR
SAVLNPLDES DRRRFLDLAA SADIVVDCGL PGQAAAYGAS CAELADRYRH LVALSITDFG
AAGPRSSWRA TDPVLYAMSG ALSRSGPTAG TPVLPPDGIA SATAAVQAAW AVLVAYFNRL
RCGTGDYIDF SRFDAVVMAL DPPFGAHGQV AAGIRSTGRW RGRPKNQDAY PIYPCRDGYV
RFCVMAPRQW RGLRRWLGEP EDFQDPKYDV IGARLAAWPQ ISVLVAKLCA EKTMKELVAA
GQALGVPITA VLTPSRILAS EHFQAVGAIT DAELVPGVRT GVPTGYFVVD GKRAGFRTPA
PAAGQDEPRW LADPAPVPPP SGRVGGYPFE GLRILDLGII VAGGELSRLF GDLGAEVIKV
ESADHPDGLR QTRVGDAMSE SFAWTHRNHL ALGLDLRNSE GKAIFGRLVA ESDAVFANFK
PGTLTSLGFS YDVLHAFNPR IVLAGSSAFG NRGPWSTRMG YGPLVRAATG VTRVWTSDEA
QPDNSRHPFY DATTIFPDHV VGRVGALLAL AALIHRDRTG GGAHVHISQA EVVVNQLDTM
FVAEAARATD VAEIHPDTSV HAVYPCAGDD EWCVISIRSD DEWRRATSVF GQPELANDPR
FGASRSRVAN RSELVAAVSA WTSTRTPVQA AGALQAAGVA AGPMNRPSDI LEDPQLIERN
LFRDMVHPLI ARPLPAETGP APFRHIPQAP QRPAPLPGQD SVQICRKLLG MTADETERLI
NERVMFGPAV TA