ID   Y1874_STRP6             Reviewed;         287 AA.
AC   Q5X9A4; Q54615; Q99XH5;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Putative sugar uptake protein M6_Spy1874;
GN   OrderedLocusNames=M6_Spy1874;
OS   Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=286636;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 21547 / S43 / Serotype M6;
RA   Weigel P.H., DeAngelis P.L.;
RT   "Unknown putative membrane protein; multiple membrane domains.";
RL   Submitted (NOV-1994) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-946 / MGAS10394;
RX   PubMed=15272401; DOI=10.1086/422697;
RA   Banks D.J., Porcella S.F., Barbian K.D., Beres S.B., Philips L.E.,
RA   Voyich J.M., DeLeo F.R., Martin J.M., Somerville G.A., Musser J.M.;
RT   "Progress toward characterization of the group A Streptococcus metagenome:
RT   complete genome sequence of a macrolide-resistant serotype M6 strain.";
RL   J. Infect. Dis. 190:727-738(2004).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the GRP transporter (TC 2.A.7.5) family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA56773.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; U17382; AAA56773.1; ALT_INIT; Genomic_DNA.
DR   EMBL; CP000003; AAT88009.1; -; Genomic_DNA.
DR   RefSeq; WP_002991450.1; NC_006086.1.
DR   AlphaFoldDB; Q5X9A4; -.
DR   SMR; Q5X9A4; -.
DR   EnsemblBacteria; AAT88009; AAT88009; M6_Spy1874.
DR   KEGG; spa:M6_Spy1874; -.
DR   HOGENOM; CLU_076024_0_0_9; -.
DR   OMA; VNTKMGG; -.
DR   Proteomes; UP000001167; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015144; F:carbohydrate transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR010651; Sugar_transport.
DR   PANTHER; PTHR16119; PTHR16119; 2.
DR   Pfam; PF06800; Sugar_transport; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Sugar transport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..287
FT                   /note="Putative sugar uptake protein M6_Spy1874"
FT                   /id="PRO_0000213665"
FT   TRANSMEM        4..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        33..50
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        55..72
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        85..107
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        117..134
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        154..171
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        181..200
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        207..229
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        234..256
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        268..285
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   287 AA;  31236 MW;  86D97F9F0B4FD37B CRC64;
     MEGIFYALIP MFTWGSIGFV SNKIGGKPSQ QTLGMTFGAL LFSLAVWLIV RPEMTLQLWL
     FGILGGFIWS IGQTGQFHAM QYMGVSVANP LSSGSQLVLG SLIGVLVFHE WTRPMQFVVG
     SLALLLLIIG FYFSSKQDDA NAQVNHLHNF SKGFRALTYS TIGYVMYAVL FNNIMKFEVL
     SVILPMAVGM VLGAITFMSF KISIDQYVIK NSVVGLLWGI GNIFMLLAAS KAGLAIAFSF
     SQLGAIISIV GGILFLGETK TKKEMRWVVT GIICFIVGAI LLGVVKS