ID   Y1877_MYCTU             Reviewed;         687 AA.
AC   P9WG85; L0T853; O07753; Q7D7V2;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 45.
DE   RecName: Full=Uncharacterized MFS-type transporter Rv1877;
GN   OrderedLocusNames=Rv1877;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. TCR/Tet
CC       family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP44643.1; -; Genomic_DNA.
DR   PIR; B70515; B70515.
DR   RefSeq; NP_216393.1; NC_000962.3.
DR   RefSeq; WP_003899060.1; NZ_NVQJ01000013.1.
DR   AlphaFoldDB; P9WG85; -.
DR   SMR; P9WG85; -.
DR   STRING; 83332.Rv1877; -.
DR   PaxDb; P9WG85; -.
DR   DNASU; 885654; -.
DR   GeneID; 45425850; -.
DR   GeneID; 885654; -.
DR   KEGG; mtu:Rv1877; -.
DR   TubercuList; Rv1877; -.
DR   eggNOG; COG0477; Bacteria.
DR   eggNOG; COG1846; Bacteria.
DR   OMA; HLTWRWA; -.
DR   PhylomeDB; P9WG85; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR005829; Sugar_transporter_CS.
DR   InterPro; IPR001958; Tet-R_TetA/multi-R_MdtG.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   PRINTS; PR01035; TCRTETA.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50850; MFS; 1.
DR   PROSITE; PS00217; SUGAR_TRANSPORT_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..687
FT                   /note="Uncharacterized MFS-type transporter Rv1877"
FT                   /id="PRO_0000390887"
FT   TRANSMEM        28..48
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        66..86
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        94..114
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        126..146
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        154..174
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        182..202
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        211..231
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        243..263
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        287..307
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        320..340
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        348..368
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        378..398
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        414..434
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        480..500
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   687 AA;  72354 MW;  34ADF744939D6964 CRC64;
     MAGPTAPTTA PTAIRAGGPL LSPVRRNIIF TALVFGVLVA ATGQTIVVPA LPTIVAELGS
     TVDQSWAVTS YLLGGTVVVV VAGKLGDLLG RNRVLLGSVV VFVVGSVLCG LSQTMTMLAI
     SRALQGVGAG AISVTAYALA AEVVPLRDRG RYQGVLGAVF GVNTVTGPLL GGWLTDYLSW
     RWAFWINVPV SIAVLTVAAT AVPALARPPK PVIDYLGILV IAVATTALIM ATSWGGTTYA
     WGSATIVGLL IGAAVALGFF VWLEGRAAAA ILPPRLFGSP VFAVCCVLSF VVGFAMLGAL
     TFVPIYLGYV DGASATASGL RTLPMVIGLL IASTGTGVLV GRTGRYKIFP VAGMALMAVA
     FLLMSQMDEW TPPLLQSLYL VVLGAGIGLS MQVLVLIVQN TSSFEDLGVA TSGVTFFRVV
     GASFGTATFG ALFVNFLDRR LGSALTSGAV PVPAVPSPAV LHQLPQSMAA PIVRAYAESL
     TQVFLCAVSV TVVGFILALL LREVPLTDIH DDADDLGDGF GVPRAESPED VLEIAVRRML
     PNGVRLRDIA TQPGCGLGVA ELWALLRIYQ YQRLFEAVRL TDIGRHLHVP YQVFEPVFDR
     LVQTGYAARD GDILTLTPSG HRQVDSLAVL IRQWLLDHLA VAPGLKRQPD HQFEAALQHV
     TDAVLVQRDW YEDLGDLSES RQLAATT