Y1887_ARATH
ID Y1887_ARATH Reviewed; 692 AA.
AC Q9SAH3;
DT 30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Putative receptor-like protein kinase At1g80870;
DE EC=2.7.11.1;
GN OrderedLocusNames=At1g80870; ORFNames=F23A5.23;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein
CC kinase family. {ECO:0000255|PROSITE-ProRule:PRU00159}.
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DR EMBL; AC011713; AAF14675.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE36462.1; -; Genomic_DNA.
DR PIR; E96841; E96841.
DR RefSeq; NP_178202.1; NM_106735.3.
DR AlphaFoldDB; Q9SAH3; -.
DR SMR; Q9SAH3; -.
DR STRING; 3702.AT1G80870.1; -.
DR iPTMnet; Q9SAH3; -.
DR PaxDb; Q9SAH3; -.
DR PRIDE; Q9SAH3; -.
DR ProteomicsDB; 232387; -.
DR EnsemblPlants; AT1G80870.1; AT1G80870.1; AT1G80870.
DR GeneID; 844427; -.
DR Gramene; AT1G80870.1; AT1G80870.1; AT1G80870.
DR KEGG; ath:AT1G80870; -.
DR Araport; AT1G80870; -.
DR TAIR; locus:2025742; AT1G80870.
DR eggNOG; KOG1187; Eukaryota.
DR HOGENOM; CLU_011728_0_0_1; -.
DR InParanoid; Q9SAH3; -.
DR OMA; GGGPCEH; -.
DR OrthoDB; 684563at2759; -.
DR PhylomeDB; Q9SAH3; -.
DR PRO; PR:Q9SAH3; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9SAH3; baseline and differential.
DR Genevisible; Q9SAH3; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0106310; F:protein serine kinase activity; IEA:RHEA.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0006468; P:protein phosphorylation; IBA:GO_Central.
DR InterPro; IPR044576; At4g25390-like.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR46821; PTHR46821; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cell membrane; Kinase; Membrane; Nucleotide-binding;
KW Reference proteome; Serine/threonine-protein kinase; Transferase;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..692
FT /note="Putative receptor-like protein kinase At1g80870"
FT /id="PRO_0000401352"
FT TRANSMEM 20..40
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 81..673
FT /note="Protein kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT REGION 427..446
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 511..533
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 206
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159,
FT ECO:0000255|PROSITE-ProRule:PRU10027"
FT BINDING 87..95
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT BINDING 109
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
SQ SEQUENCE 692 AA; 78550 MW; 5DBAB6A5EF05A137 CRC64;
MPSRPNPTRP KLFHNRTKTL FLILTISSSL VIFFAILYFI YHLWISLLNR SRTIPFDVAA
ASPLKLQLFT YKELKLATND FDESNVIGKG GSGTVFRGIT RDGKLFAVKR LDNLSIQTET
EFQNELQILG GLKSSFLVTL LGYCVEKNHR FLIYEYMPNK SLQELLFNED GDSCLNWERR
FGIILDVAKA LEFMHFGCDP PVIHGDIKPS NVLLDSEFRA KISDFGLSRV KVEGGYGVDL
FSQELSGNFG GESTPQTAIG TPTHHEVDFA LALQASSSSK NSRTSRNIKE MSLNSMSLAM
DGETKGKEVS NDVVLSCEDH EFDQGKEMNL LSPNSVLDLG KGSKQWGRDW WWKQEGSGEL
CSKDYVREWI GSQIDTANPD WDDDKKVITT PELGVSTRTI DKAEHRDESG LNESRFDTLE
EKFAKEEISE RKNKRSKNKK KKHRNMEEWW KEEEHQEEMN NKKKIGVLRI KFKNHLKFPH
FRYCFRQKGE NSVHDREGEA AGEFSFRRGW RRKSNSSSKK KKKNNNGSMG SEMWSGDLFS
RELSSTTSMR GTLCYIAPEY GGGCCYLMEK GDIYSFGVLI LVIVSGRRPL HVLASPMKLE
KANLVSWCRQ LAQSGNVLEL VDEKLKDGYN KEEAGLCINL ALACLQKAPE LRPDVSEVVR
ILRGEMDISS TAFEFSPSPP GKVYGSRSKR RS
