ID   Y1888_MYCS2             Reviewed;         310 AA.
AC   A0QTL6; I7F9S1;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Putative S-adenosyl-L-methionine-dependent methyltransferase MSMEG_1888/MSMEI_1848;
DE            EC=2.1.1.-;
GN   OrderedLocusNames=MSMEG_1888, MSMEI_1848;
OS   Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium
OS   smegmatis).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycolicibacterium.
OX   NCBI_TaxID=246196;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700084 / mc(2)155;
RA   Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C.,
RA   Fraser C.M.;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700084 / mc(2)155;
RX   PubMed=17295914; DOI=10.1186/gb-2007-8-2-r20;
RA   Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C.,
RA   Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.;
RT   "Interrupted coding sequences in Mycobacterium smegmatis: authentic
RT   mutations or sequencing errors?";
RL   Genome Biol. 8:R20.1-R20.9(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700084 / mc(2)155;
RX   PubMed=18955433; DOI=10.1101/gr.081901.108;
RA   Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M.,
RA   Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.;
RT   "Ortho-proteogenomics: multiple proteomes investigation through orthology
RT   and a new MS-based protocol.";
RL   Genome Res. 19:128-135(2009).
CC   -!- FUNCTION: Exhibits S-adenosyl-L-methionine-dependent methyltransferase
CC       activity. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UPF0677 family. {ECO:0000305}.
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DR   EMBL; CP000480; ABK71680.1; -; Genomic_DNA.
DR   EMBL; CP001663; AFP38320.1; -; Genomic_DNA.
DR   RefSeq; WP_011727981.1; NZ_SIJM01000020.1.
DR   RefSeq; YP_886254.1; NC_008596.1.
DR   AlphaFoldDB; A0QTL6; -.
DR   SMR; A0QTL6; -.
DR   STRING; 246196.MSMEI_1848; -.
DR   EnsemblBacteria; ABK71680; ABK71680; MSMEG_1888.
DR   EnsemblBacteria; AFP38320; AFP38320; MSMEI_1848.
DR   GeneID; 66733323; -.
DR   KEGG; msg:MSMEI_1848; -.
DR   KEGG; msm:MSMEG_1888; -.
DR   PATRIC; fig|246196.19.peg.1870; -.
DR   eggNOG; COG3315; Bacteria.
DR   OMA; GMQRMTD; -.
DR   OrthoDB; 847145at2; -.
DR   Proteomes; UP000000757; Chromosome.
DR   Proteomes; UP000006158; Chromosome.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR011610; CHP00027_methylltransferase.
DR   InterPro; IPR007213; Ppm1/Ppm2/Tcmp.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   Pfam; PF04072; LCM; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   TIGRFAMs; TIGR00027; mthyl_TIGR00027; 1.
PE   3: Inferred from homology;
KW   Methyltransferase; Reference proteome; S-adenosyl-L-methionine;
KW   Transferase.
FT   CHAIN           1..310
FT                   /note="Putative S-adenosyl-L-methionine-dependent
FT                   methyltransferase MSMEG_1888/MSMEI_1848"
FT                   /id="PRO_0000361199"
FT   BINDING         128
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
FT   BINDING         157..158
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   310 AA;  33140 MW;  7EC29DEDA296D8C2 CRC64;
     MESTHETWDL ATSVGATATM VAAGRARATT TGLIDDRFAE PLVRAVGIDF MTRWATGDLA
     AADVDIPGAT WGMQQMTDLL AARTRYFDAF FGDAAAAGVR QAVILASGLD ARGYRLDWPA
     GTVLFEIDMP DVLEFKGRAL TDLRAEPTAE VRMVAVDLRD DWPAALRAKG FDPTRPTAWS
     AEGLLPFLPP EAQDRLLDAI TSLSASGSRL AAEVALLGSD SEDGALGADG ARDLEPLLAR
     WREHGFDLDL GDLGNSGPRN DVDDYLEARG WTSTRTPLAA LLDAAGLEVP RPADGRKSLS
     DNYYSTAIKG