ID   Y189_CLOPE              Reviewed;         279 AA.
AC   P26833;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   25-MAY-2022, entry version 121.
DE   RecName: Full=Uncharacterized HTH-type transcriptional regulator CPE0189;
GN   OrderedLocusNames=CPE0189;
OS   Clostridium perfringens (strain 13 / Type A).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=195102;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=CPN50;
RX   PubMed=8177218; DOI=10.1007/bf00280319;
RA   Canard B., Garnier T., Saint-Joanis B., Cole S.T.;
RT   "Molecular genetic analysis of the nagH gene encoding a hyaluronidase of
RT   Clostridium perfringens.";
RL   Mol. Gen. Genet. 243:215-224(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=13 / Type A;
RX   PubMed=11792842; DOI=10.1073/pnas.022493799;
RA   Shimizu T., Ohtani K., Hirakawa H., Ohshima K., Yamashita A., Shiba T.,
RA   Ogasawara N., Hattori M., Kuhara S., Hayashi H.;
RT   "Complete genome sequence of Clostridium perfringens, an anaerobic flesh-
RT   eater.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:996-1001(2002).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; M81878; AAA23257.1; -; Genomic_DNA.
DR   EMBL; BA000016; BAB79895.1; -; Genomic_DNA.
DR   PIR; S43902; S43902.
DR   RefSeq; WP_003457572.1; NC_003366.1.
DR   AlphaFoldDB; P26833; -.
DR   SMR; P26833; -.
DR   STRING; 195102.gene:10489433; -.
DR   EnsemblBacteria; BAB79895; BAB79895; BAB79895.
DR   GeneID; 29572696; -.
DR   KEGG; cpe:CPE0189; -.
DR   HOGENOM; CLU_055769_0_0_9; -.
DR   OMA; PNLIPHI; -.
DR   Proteomes; UP000000818; Chromosome.
DR   GO; GO:0097367; F:carbohydrate derivative binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:1901135; P:carbohydrate derivative metabolic process; IEA:InterPro.
DR   CDD; cd05013; SIS_RpiR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR000281; HTH_RpiR.
DR   InterPro; IPR035472; RpiR-like_SIS.
DR   InterPro; IPR001347; SIS_dom.
DR   InterPro; IPR046348; SIS_dom_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF01418; HTH_6; 1.
DR   Pfam; PF01380; SIS; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF53697; SSF53697; 1.
DR   PROSITE; PS51071; HTH_RPIR; 1.
DR   PROSITE; PS51464; SIS; 1.
PE   4: Predicted;
KW   DNA-binding; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..279
FT                   /note="Uncharacterized HTH-type transcriptional regulator
FT                   CPE0189"
FT                   /id="PRO_0000068631"
FT   DOMAIN          1..77
FT                   /note="HTH rpiR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00390"
FT   DOMAIN          123..263
FT                   /note="SIS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00797"
FT   DNA_BIND        37..56
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00390"
SQ   SEQUENCE   279 AA;  31254 MW;  F40B1203634A65AA CRC64;
     MGILEQLENP KFKATKSEKT LIEYIKSDLD NIIYKSISII AKESGVGEAT ITRFTKKLGF
     NGFQDFKVTL AKEISNKKNT SIINLHVHRD ESVTETANKM LKSSINILEQ TVKQIDLDLM
     CKCRDLIMNA KRVYFIGIGY SGIAATDINY KFMRIGFTTV PVTDSHTMVI MSSITNDDDV
     IVAISNSGTT KEVIKTVKQA KENGTKIITL TEDSDNPLRK LSDYELTYTS AETIFETGSI
     SSKIPQIFLL DLLYTEVIKE MFSEAVEKKI KTTSAILND