ID   Y1901_AQUAE             Reviewed;         135 AA.
AC   O67739;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=VapC ribonuclease aq_1901;
DE            Short=RNase aq_1901;
DE            EC=3.1.-.-;
DE   AltName: Full=Toxin aq_1901;
GN   OrderedLocusNames=aq_1901;
OS   Aquifex aeolicus (strain VF5).
OC   Bacteria; Aquificae; Aquificales; Aquificaceae; Aquifex.
OX   NCBI_TaxID=224324;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VF5;
RX   PubMed=9537320; DOI=10.1038/32831;
RA   Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L.,
RA   Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R.,
RA   Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.;
RT   "The complete genome of the hyperthermophilic bacterium Aquifex aeolicus.";
RL   Nature 392:353-358(1998).
CC   -!- FUNCTION: Toxic component of a type II toxin-antitoxin (TA) system. An
CC       RNase (By similarity). {ECO:0000250}.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000305};
CC   -!- SIMILARITY: Belongs to the PINc/VapC protein family. {ECO:0000305}.
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DR   EMBL; AE000657; AAC07709.1; -; Genomic_DNA.
DR   RefSeq; NP_214307.1; NC_000918.1.
DR   RefSeq; WP_010881243.1; NC_000918.1.
DR   AlphaFoldDB; O67739; -.
DR   SMR; O67739; -.
DR   STRING; 224324.aq_1899b; -.
DR   EnsemblBacteria; AAC07709; AAC07709; aq_1899b.
DR   KEGG; aae:aq_1899b; -.
DR   eggNOG; COG5611; Bacteria.
DR   HOGENOM; CLU_121449_2_2_0; -.
DR   InParanoid; O67739; -.
DR   OMA; WEREDIY; -.
DR   OrthoDB; 2195036at2; -.
DR   Proteomes; UP000000798; Chromosome.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004518; F:nuclease activity; IEA:UniProtKB-KW.
DR   InterPro; IPR029060; PIN-like_dom_sf.
DR   InterPro; IPR002716; PIN_dom.
DR   Pfam; PF01850; PIN; 1.
DR   SUPFAM; SSF88723; SSF88723; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Magnesium; Metal-binding; Nuclease; Reference proteome;
KW   Toxin-antitoxin system.
FT   CHAIN           1..135
FT                   /note="VapC ribonuclease aq_1901"
FT                   /id="PRO_0000186957"
FT   DOMAIN          3..130
FT                   /note="PINc"
FT   BINDING         5
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   135 AA;  15984 MW;  9C9B90271BFF267D CRC64;
     MKLLDTTVLL DFLSGEEEKV ETIEQFFEEL SQKGEKLFVP EEVIIELVYF LEHGYKWERE
     DIYEVVETIL NDELFNVELK PFIREAIKLY SKRQGTFLDC LKSVKAKKMG IKEVVSFGRR
     FKKLGFKTVN PYEES