ID   Y190_HELPJ              Reviewed;         502 AA.
AC   Q9ZMP2;
DT   11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Uncharacterized protein jhp_0176;
GN   OrderedLocusNames=jhp_0176;
OS   Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=85963;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=J99 / ATCC 700824;
RX   PubMed=9923682; DOI=10.1038/16495;
RA   Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C.,
RA   Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J.,
RA   Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D.,
RA   Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J.;
RT   "Genomic sequence comparison of two unrelated isolates of the human gastric
RT   pathogen Helicobacter pylori.";
RL   Nature 397:176-180(1999).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the phospholipase D family. Cardiolipin synthase
CC       subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE001439; AAD05760.1; -; Genomic_DNA.
DR   PIR; E71963; E71963.
DR   RefSeq; WP_000689052.1; NZ_CP011330.1.
DR   AlphaFoldDB; Q9ZMP2; -.
DR   STRING; 85963.jhp_0176; -.
DR   EnsemblBacteria; AAD05760; AAD05760; jhp_0176.
DR   KEGG; hpj:jhp_0176; -.
DR   PATRIC; fig|85963.30.peg.845; -.
DR   eggNOG; COG1502; Bacteria.
DR   OMA; WHLVVYR; -.
DR   Proteomes; UP000000804; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0019637; P:organophosphate metabolic process; IEA:UniProt.
DR   InterPro; IPR025202; PLD-like_dom.
DR   InterPro; IPR001736; PLipase_D/transphosphatidylase.
DR   Pfam; PF13091; PLDc_2; 2.
DR   SMART; SM00155; PLDc; 2.
DR   PROSITE; PS50035; PLD; 2.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Repeat; Transferase; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..502
FT                   /note="Uncharacterized protein jhp_0176"
FT                   /id="PRO_0000201291"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          162..189
FT                   /note="PLD phosphodiesterase 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00153"
FT   DOMAIN          396..423
FT                   /note="PLD phosphodiesterase 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00153"
SQ   SEQUENCE   502 AA;  58146 MW;  802477EBFC5775A1 CRC64;
     MKIFLVILSV FFFNGCFGLA YKTPISNPPI SYDPYTTTIG SLYAKNLKEN PKHSAAILLE
     DGFDALLHRV GLIRMSQKSI DMQTYIYKND LSSQVIAKEL LNAANRGVKV RILLDDNGLD
     SDFSDIMLLN FHKNIEVKIF NPYYIRNKGL RYFEMLADYE RIKKRMHNKL FIVDNFAVII
     GGRNIGDNYF DNDLDTNFLD LDALFFGGVA SKAKESFENY WRFHRSIPVS LLRTHKRLKN
     NVKEIAKLHE KIPISAEDAN EFEKKVNDFI ERFQKYQYPI YYGNAIFLAD LPAKIDTPLY
     SPIKIAFEKA LKNAKDSVFI ASSYFIPGKK IMKIFKNQIS KGIELNILTN SLSSTDAIVV
     YGAWERYRNK LVRMGANVYE IRNDFFNRQI KGRFSTKHSL HGKTIVFDDA LTLLGSFNID
     PRSAYINTES AVLFDNPSFA KRVRLSLKDH AQQSWHLVLY RHRVIWEATE EGILIHEKNS
     PDTSFFLRLI KEWSKVLPER EL