ID   Y190_HELPY              Reviewed;         502 AA.
AC   P56117;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 105.
DE   RecName: Full=Uncharacterized protein HP_0190;
GN   OrderedLocusNames=HP_0190;
OS   Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=85962;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700392 / 26695;
RX   PubMed=9252185; DOI=10.1038/41483;
RA   Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA   Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A.,
RA   Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N.,
RA   Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A.,
RA   McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E.,
RA   Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D.,
RA   Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S.,
RA   Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
RT   "The complete genome sequence of the gastric pathogen Helicobacter
RT   pylori.";
RL   Nature 388:539-547(1997).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the phospholipase D family. Cardiolipin synthase
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AE000511; AAD07257.1; -; Genomic_DNA.
DR   PIR; F64543; F64543.
DR   RefSeq; NP_206989.1; NC_000915.1.
DR   RefSeq; WP_000689051.1; NC_018939.1.
DR   AlphaFoldDB; P56117; -.
DR   STRING; 85962.C694_00945; -.
DR   PaxDb; P56117; -.
DR   EnsemblBacteria; AAD07257; AAD07257; HP_0190.
DR   KEGG; hpy:HP_0190; -.
DR   PATRIC; fig|85962.47.peg.205; -.
DR   eggNOG; COG1502; Bacteria.
DR   OMA; WHLVVYR; -.
DR   PhylomeDB; P56117; -.
DR   Proteomes; UP000000429; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032049; P:cardiolipin biosynthetic process; IBA:GO_Central.
DR   InterPro; IPR025202; PLD-like_dom.
DR   InterPro; IPR001736; PLipase_D/transphosphatidylase.
DR   Pfam; PF13091; PLDc_2; 2.
DR   SMART; SM00155; PLDc; 2.
DR   PROSITE; PS50035; PLD; 2.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Repeat; Transferase;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..502
FT                   /note="Uncharacterized protein HP_0190"
FT                   /id="PRO_0000201290"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          162..189
FT                   /note="PLD phosphodiesterase 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00153"
FT   DOMAIN          396..423
FT                   /note="PLD phosphodiesterase 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00153"
SQ   SEQUENCE   502 AA;  58287 MW;  C80911F2FB59C714 CRC64;
     MKIFLVFLSV FFFNGCFGLV YKTPISSSPI SYDPYTTPIG SLYAEKLKEN PNHSAAILLE
     DGFDALLHRV GLIRMSQKSI DMQTYIYKND LSSQVIAKEL LNAANRGVKV RILLDDNGLD
     SDFSDIMLLN FHKNIEVKIF NPYYIRNKGL RYFEMLADYE RIKKRMHNKL FIVDNFAVII
     GGRNIGDNYF DNDLDTNFLD LDALFFGGVA SKAKESFERY WRFHRSIPVS LLRTHKRLKN
     NAKEIAKLHE KIPISAEDKN QFEKKVNDFI DRFQKYQYPI YYGNAIFLAD SPKKIDTPLY
     SPIKIAFEKA LKNAKDSVFI ASSYFIPGKK MMKIFKNQIS KGIELNILTN SLSSTDAIVV
     YGAWERYRNQ LVRMGANVYE IRNDFFNRQI KGRFSTKHSL HGKTIVFDDN LTLLGSFNID
     PRSAYINTES AVLFDNPSFA KRVRLSLKDH AQQSWHLVVY RHRVIWEAVE EGILIHEKTS
     PDTSFFLRLI KEWSKVLPER EL