ID   Y1931_MYCTU             Reviewed;         259 AA.
AC   P95283; I6XZB7; L0T8A6;
DT   30-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 4.
DT   03-AUG-2022, entry version 148.
DE   RecName: Full=HTH-type transcriptional regulator Rv1931c {ECO:0000303|PubMed:15322050};
GN   OrderedLocusNames=Rv1931c;
GN   ORFNames=LH57_10510 {ECO:0000312|EMBL:AIR14676.1};
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27294 / TMC 102 / H37Rv;
RA   Hazbon M.H., Riojas M.A., Damon A.M., Alalade R.O., Cantwell B.J.,
RA   Monaco A., King S., Sohrabi A.;
RT   "Phylogenetic analysis of Mycobacterial species using whole genome
RT   sequences.";
RL   Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=15322050; DOI=10.1128/iai.72.9.5483-5486.2004;
RA   Frota C.C., Papavinasasundaram K.G., Davis E.O., Colston M.J.;
RT   "The AraC family transcriptional regulator Rv1931c plays a role in the
RT   virulence of Mycobacterium tuberculosis.";
RL   Infect. Immun. 72:5483-5486(2004).
RN   [4]
RP   INDUCTION.
RX   PubMed=19389781; DOI=10.1099/mic.0.027086-0;
RA   de la Paz Santangelo M., Klepp L., Nunez-Garcia J., Blanco F.C., Soria M.,
RA   Garcia-Pelayo M.C., Bianco M.V., Cataldi A.A., Golby P., Jackson M.,
RA   Gordon S.V., Bigi F.;
RT   "Mce3R, a TetR-type transcriptional repressor, controls the expression of a
RT   regulon involved in lipid metabolism in Mycobacterium tuberculosis.";
RL   Microbiology 155:2245-2255(2009).
CC   -!- FUNCTION: Controls the expression of genes important for virulence.
CC       {ECO:0000269|PubMed:15322050}.
CC   -!- INDUCTION: Repressed by Mce3R. {ECO:0000269|PubMed:19389781}.
CC   -!- DISRUPTION PHENOTYPE: Cells lacking this gene exhibit reduced survival
CC       both in macrophages and in a mouse infection model.
CC       {ECO:0000269|PubMed:15322050}.
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DR   EMBL; CP009480; AIR14676.1; -; Genomic_DNA.
DR   EMBL; AL123456; CCP44698.1; -; Genomic_DNA.
DR   RefSeq; NP_216447.1; NC_000962.3.
DR   RefSeq; WP_003899087.1; NC_000962.3.
DR   AlphaFoldDB; P95283; -.
DR   SMR; P95283; -.
DR   STRING; 83332.Rv1931c; -.
DR   PaxDb; P95283; -.
DR   DNASU; 885437; -.
DR   GeneID; 885437; -.
DR   KEGG; mtu:Rv1931c; -.
DR   PATRIC; fig|83332.111.peg.2148; -.
DR   TubercuList; Rv1931c; -.
DR   eggNOG; COG4977; Bacteria.
DR   HOGENOM; CLU_000445_59_0_11; -.
DR   OMA; CVATTHW; -.
DR   PhylomeDB; P95283; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; NAS:UniProtKB.
DR   Gene3D; 3.40.50.880; -; 1.
DR   InterPro; IPR029062; Class_I_gatase-like.
DR   InterPro; IPR002818; DJ-1/PfpI.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR018060; HTH_AraC.
DR   Pfam; PF01965; DJ-1_PfpI; 1.
DR   Pfam; PF12833; HTH_18; 1.
DR   SMART; SM00342; HTH_ARAC; 1.
DR   SUPFAM; SSF46689; SSF46689; 2.
DR   SUPFAM; SSF52317; SSF52317; 1.
DR   PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Reference proteome; Transcription; Transcription regulation;
KW   Virulence.
FT   CHAIN           1..259
FT                   /note="HTH-type transcriptional regulator Rv1931c"
FT                   /id="PRO_0000438537"
FT   DOMAIN          174..257
FT                   /note="HTH araC/xylS-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        176..197
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        224..247
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   REGION          104..170
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   259 AA;  27996 MW;  3A85982D3420E5CB CRC64;
     MVIVGFPGDP VDTVILPGGA GVDAARSEPA LIDWVKAVSG TARRVVTVCT GAFLAAEAGL
     LGRTPSDDAL GLCRTFRPRI SGRSGRCRPD LHAQFAEGVD RGWSHRRHRP RAGTGRRRPR
     HRDCPDGCPL ARPVSAPTRW ADPVRGSGVD ATRQTDLDPP GAGGHRGRAG GAHRIGELAQ
     RAAMSPRHFT RVFSDEVGEA PGRYVERIRT EAARRQLEET HDTVVAIAAR CGFGTAETMR
     RSFIRRVGIS PDQYRKAFA