CAPSL_HUMAN
ID CAPSL_HUMAN Reviewed; 208 AA.
AC Q8WWF8;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 4.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Calcyphosin-like protein;
GN Name=CAPSL;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15372022; DOI=10.1038/nature02919;
RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT "The DNA sequence and comparative analysis of human chromosome 5.";
RL Nature 431:268-274(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH17586.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC112204; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC017586; AAH17586.2; ALT_INIT; mRNA.
DR CCDS; CCDS3912.2; -.
DR RefSeq; NP_001036090.1; NM_001042625.1.
DR RefSeq; NP_653248.3; NM_144647.3.
DR AlphaFoldDB; Q8WWF8; -.
DR SMR; Q8WWF8; -.
DR BioGRID; 126371; 15.
DR STRING; 9606.ENSP00000380524; -.
DR iPTMnet; Q8WWF8; -.
DR MetOSite; Q8WWF8; -.
DR PhosphoSitePlus; Q8WWF8; -.
DR BioMuta; CAPSL; -.
DR DMDM; 296439463; -.
DR MassIVE; Q8WWF8; -.
DR PaxDb; Q8WWF8; -.
DR PeptideAtlas; Q8WWF8; -.
DR PRIDE; Q8WWF8; -.
DR ProteomicsDB; 74883; -.
DR Antibodypedia; 43514; 40 antibodies from 17 providers.
DR DNASU; 133690; -.
DR Ensembl; ENST00000397366.5; ENSP00000380523.1; ENSG00000152611.12.
DR Ensembl; ENST00000397367.6; ENSP00000380524.2; ENSG00000152611.12.
DR Ensembl; ENST00000651391.1; ENSP00000498465.1; ENSG00000152611.12.
DR GeneID; 133690; -.
DR KEGG; hsa:133690; -.
DR MANE-Select; ENST00000651391.1; ENSP00000498465.1; NM_001042625.2; NP_001036090.1.
DR UCSC; uc003jjt.2; human.
DR CTD; 133690; -.
DR DisGeNET; 133690; -.
DR GeneCards; CAPSL; -.
DR HGNC; HGNC:28375; CAPSL.
DR HPA; ENSG00000152611; Tissue enriched (fallopian).
DR MIM; 618799; gene.
DR neXtProt; NX_Q8WWF8; -.
DR OpenTargets; ENSG00000152611; -.
DR PharmGKB; PA142672204; -.
DR VEuPathDB; HostDB:ENSG00000152611; -.
DR eggNOG; KOG0032; Eukaryota.
DR GeneTree; ENSGT00940000156466; -.
DR HOGENOM; CLU_036726_1_0_1; -.
DR InParanoid; Q8WWF8; -.
DR OMA; VYHAERH; -.
DR OrthoDB; 1377102at2759; -.
DR PhylomeDB; Q8WWF8; -.
DR TreeFam; TF318191; -.
DR PathwayCommons; Q8WWF8; -.
DR SignaLink; Q8WWF8; -.
DR BioGRID-ORCS; 133690; 12 hits in 1056 CRISPR screens.
DR GenomeRNAi; 133690; -.
DR Pharos; Q8WWF8; Tdark.
DR PRO; PR:Q8WWF8; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q8WWF8; protein.
DR Bgee; ENSG00000152611; Expressed in bronchial epithelial cell and 94 other tissues.
DR ExpressionAtlas; Q8WWF8; baseline and differential.
DR Genevisible; Q8WWF8; HS.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR InterPro; IPR029633; CAPSL.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR PANTHER; PTHR34524:SF5; PTHR34524:SF5; 1.
DR Pfam; PF13499; EF-hand_7; 2.
DR SMART; SM00054; EFh; 4.
DR SUPFAM; SSF47473; SSF47473; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 4.
PE 2: Evidence at transcript level;
KW Calcium; Cytoplasm; Metal-binding; Reference proteome; Repeat.
FT CHAIN 1..208
FT /note="Calcyphosin-like protein"
FT /id="PRO_0000264473"
FT DOMAIN 39..74
FT /note="EF-hand 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 75..110
FT /note="EF-hand 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 111..146
FT /note="EF-hand 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 154..191
FT /note="EF-hand 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 52
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 54
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 56
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 58
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 63
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 88
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 90
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 92
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 94
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 99
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT VARIANT 85
FT /note="R -> Q (in dbSNP:rs1445898)"
FT /id="VAR_029631"
FT VARIANT 201
FT /note="M -> V (in dbSNP:rs1345826)"
FT /id="VAR_029632"
FT CONFLICT 24
FT /note="D -> N (in Ref. 2; AAH17586)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 208 AA; 24229 MW; 4F1C9D89F13C538E CRC64;
MAGTARHDRE MAIQAKKKLT TATDPIERLR LQCLARGSAG IKGLGRVFRI MDDDNNRTLD
FKEFMKGLND YAVVMEKEEV EELFRRFDKD GNGTIDFNEF LLTLRPPMSR ARKEVIMQAF
RKLDKTGDGV ITIEDLREVY NAKHHPKYQN GEWSEEQVFR KFLDNFDSPY DKDGLVTPEE
FMNYYAGVSA SIDTDVYFII MMRTAWKL
