ID   Y1936_STRP1             Reviewed;         286 AA.
AC   P67374; Q48WK7; Q99Y04;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=DegV domain-containing protein SPy_1936/M5005_Spy1650;
GN   OrderedLocusNames=SPy_1936, M5005_Spy1650;
OS   Streptococcus pyogenes serotype M1.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=301447;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700294 / SF370 / Serotype M1;
RX   PubMed=11296296; DOI=10.1073/pnas.071559398;
RA   Ferretti J.J., McShan W.M., Ajdic D.J., Savic D.J., Savic G., Lyon K.,
RA   Primeaux C., Sezate S., Suvorov A.N., Kenton S., Lai H.S., Lin S.P.,
RA   Qian Y., Jia H.G., Najar F.Z., Ren Q., Zhu H., Song L., White J., Yuan X.,
RA   Clifton S.W., Roe B.A., McLaughlin R.E.;
RT   "Complete genome sequence of an M1 strain of Streptococcus pyogenes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:4658-4663(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-947 / MGAS5005 / Serotype M1;
RX   PubMed=16088826; DOI=10.1086/432514;
RA   Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K.,
RA   Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P.,
RA   Musser J.M.;
RT   "Evolutionary origin and emergence of a highly successful clone of serotype
RT   M1 group A Streptococcus involved multiple horizontal gene transfer
RT   events.";
RL   J. Infect. Dis. 192:771-782(2005).
CC   -!- FUNCTION: May bind long-chain fatty acids, such as palmitate, and may
CC       play a role in lipid transport or fatty acid metabolism. {ECO:0000250}.
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DR   EMBL; AE004092; AAK34634.1; -; Genomic_DNA.
DR   EMBL; CP000017; AAZ52268.1; -; Genomic_DNA.
DR   RefSeq; NP_269913.1; NC_002737.2.
DR   AlphaFoldDB; P67374; -.
DR   SMR; P67374; -.
DR   STRING; 1314.HKU360_01770; -.
DR   PaxDb; P67374; -.
DR   EnsemblBacteria; AAK34634; AAK34634; SPy_1936.
DR   KEGG; spy:SPy_1936; -.
DR   KEGG; spz:M5005_Spy1650; -.
DR   PATRIC; fig|160490.10.peg.1683; -.
DR   HOGENOM; CLU_048251_4_1_9; -.
DR   OMA; LWPASIH; -.
DR   Proteomes; UP000000750; Chromosome.
DR   GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.1180.10; -; 1.
DR   InterPro; IPR003797; DegV.
DR   InterPro; IPR043168; DegV_C.
DR   Pfam; PF02645; DegV; 1.
DR   TIGRFAMs; TIGR00762; DegV; 1.
DR   PROSITE; PS51482; DEGV; 1.
PE   3: Inferred from homology;
KW   Lipid-binding; Reference proteome.
FT   CHAIN           1..286
FT                   /note="DegV domain-containing protein
FT                   SPy_1936/M5005_Spy1650"
FT                   /id="PRO_0000209812"
FT   DOMAIN          3..282
FT                   /note="DegV"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00815"
FT   BINDING         62
FT                   /ligand="hexadecanoate"
FT                   /ligand_id="ChEBI:CHEBI:7896"
FT                   /evidence="ECO:0000250|UniProtKB:Q9X1H9"
FT   BINDING         94
FT                   /ligand="hexadecanoate"
FT                   /ligand_id="ChEBI:CHEBI:7896"
FT                   /evidence="ECO:0000250|UniProtKB:Q9X1H9"
SQ   SEQUENCE   286 AA;  31380 MW;  F67C179B79AD62A5 CRC64;
     MTFTIMTDST ADLNQTWAED HDIVLIGLTI LCDGEVYETV GPNRISSDYL LKKMKAGSHP
     QTSQINVGEF EKVFREHARN NKALLYLAFS SVLSGTYQSA LMARDLVRED YPDAVIEIVD
     TLAAAGGEGY LTILAAEARD SGKNLLETKD IVEAVIPRLR TYFLVDDLFH LMRGGRLSKG
     SAFLGSLASI KPLLWIDEEG KLVPIAKIRG RQKAIKEMVA QVEKDIADST VIVSYTSDQG
     SAEKLREELL AHENISDVLM MPLGPVISAH VGPNTLAVFV IGQNSR