ID   Y1937_STAAR             Reviewed;         374 AA.
AC   Q6GFL0;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=UPF0754 membrane protein SAR1937;
GN   OrderedLocusNames=SAR1937;
OS   Staphylococcus aureus (strain MRSA252).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=282458;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MRSA252;
RX   PubMed=15213324; DOI=10.1073/pnas.0402521101;
RA   Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J.,
RA   Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A.,
RA   Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C.,
RA   Clark L., Corton C., Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z.,
RA   Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N.,
RA   Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A.,
RA   Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M.,
RA   Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J.;
RT   "Complete genomes of two clinical Staphylococcus aureus strains: evidence
RT   for the rapid evolution of virulence and drug resistance.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UPF0754 family. {ECO:0000305}.
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DR   EMBL; BX571856; CAG40924.1; -; Genomic_DNA.
DR   RefSeq; WP_000992536.1; NC_002952.2.
DR   AlphaFoldDB; Q6GFL0; -.
DR   KEGG; sar:SAR1937; -.
DR   HOGENOM; CLU_042384_0_0_9; -.
DR   OMA; DTIMGSL; -.
DR   OrthoDB; 373600at2; -.
DR   Proteomes; UP000000596; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR007383; DUF445.
DR   InterPro; IPR016991; UCP032178.
DR   Pfam; PF04286; DUF445; 1.
DR   PIRSF; PIRSF032178; UCP032178; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..374
FT                   /note="UPF0754 membrane protein SAR1937"
FT                   /id="PRO_0000388308"
FT   TRANSMEM        4..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        354..374
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   374 AA;  42676 MW;  794925874877F9EB CRC64;
     MNALFIIIFM IVVGAIIGGV TNVIAIRMLF HPFKPYYIFK FRVPFTPGLI PKRREEIATK
     IGQVIEEHLL TETLINEKLK SEQSQQAIES MIQQQLQKLT KDQLSIKQIT SQIDIDLEQV
     LQTNGNQYIA SQLNNYYTKH QNQTIASLLP NQLVTFLDQH VDNATDLLCD RARNYLSSAK
     GTQDINDMLD TFFNEKGKLI GMLQMFMTKE SIADRIQQEL IRLTSHPKAR AIVTSLITNE
     YQTFKDKSLN KLLDTSQFNE IAENLSMYVT TYASKQANKP VVTLMPQFVD YLESQLSSKL
     ANLIIEQLSI HLSTIMKKVD LRGLIEEQIN TFDLDYIEKL IIEIANKELK LIMSLGFILG
     GIIGFFQGLV AIFV