ID   Y1945_MYCTU             Reviewed;         454 AA.
AC   P9WLQ5; L0T860; P95269;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 37.
DE   RecName: Full=Uncharacterized protein Rv1945;
GN   OrderedLocusNames=Rv1945; ORFNames=MTCY09F9.19c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- SIMILARITY: Belongs to the Rv1128c/1148c/1588c/1702c/1945/3466 family.
CC       {ECO:0000305}.
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DR   EMBL; AL123456; CCP44712.1; -; Genomic_DNA.
DR   PIR; E70637; E70637.
DR   RefSeq; NP_216461.1; NC_000962.3.
DR   RefSeq; WP_003903691.1; NZ_KK339370.1.
DR   AlphaFoldDB; P9WLQ5; -.
DR   STRING; 83332.Rv1945; -.
DR   PaxDb; P9WLQ5; -.
DR   DNASU; 885980; -.
DR   GeneID; 885980; -.
DR   KEGG; mtu:Rv1945; -.
DR   TubercuList; Rv1945; -.
DR   eggNOG; COG1403; Bacteria.
DR   OMA; WCEGHHI; -.
DR   PhylomeDB; P9WLQ5; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0004519; F:endonuclease activity; IEA:InterPro.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   CDD; cd00085; HNHc; 1.
DR   InterPro; IPR003870; DUF222.
DR   InterPro; IPR002711; HNH.
DR   InterPro; IPR003615; HNH_nuc.
DR   Pfam; PF02720; DUF222; 1.
DR   Pfam; PF01844; HNH; 1.
DR   SMART; SM00507; HNHc; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..454
FT                   /note="Uncharacterized protein Rv1945"
FT                   /id="PRO_0000103914"
FT   DOMAIN          364..405
FT                   /note="HNH"
FT   REGION          415..434
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   454 AA;  49671 MW;  63D8EB2D4A3A9534 CRC64;
     MRSDTREEIS AALDAYHASL SRVLDLKCDA LTTPELLACL QRLEVERRRQ GAAEHALINQ
     LAGQACEEEL GGTLRTALAN RLHITPGEAS RRIAEAEDLG ERRALTGEPL PAQLTATAAA
     QREGKIGREH IKEIQAFFKE LSAAVDLGIR EAAEAQLAEL ATSRRPDHLH GLATQLMDWL
     HPDGNFSDQE RARKRGITMG KQEFDGMSRI SGLLTPELRA TIEAVLAKLA APGACNPDDQ
     TPVVDDTPDA DAVRRDTRSQ AQRHHDGLLA GLRGLLASGE LGQHRGLPVT VVVSTTLKEL
     EAATGKGVTG GGSRVPMSDL IRMASNAHHY LALFDGAKPL ALYHTKRLAS PAQRIMLYAK
     DRGCSRPGCD APAYHSEVHH VTPWTTTHRT DINDLTLACG PDNRLVEKGW KTRKNAKGDT
     EWLPPAHLDH GQPRINRYHH PEKILCEPDD DEPH