ID   CAPSP_ADECR             Reviewed;         477 AA.
AC   P68947; Q65950;
DT   01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   12-AUG-2020, entry version 50.
DE   RecName: Full=Penton protein {ECO:0000255|HAMAP-Rule:MF_04052};
DE            Short=CP-P {ECO:0000255|HAMAP-Rule:MF_04052};
DE   AltName: Full=Penton base protein {ECO:0000255|HAMAP-Rule:MF_04052};
DE   AltName: Full=Protein III {ECO:0000255|HAMAP-Rule:MF_04052};
GN   Name=L2 {ECO:0000255|HAMAP-Rule:MF_04052};
OS   Canine adenovirus serotype 1 (strain RI261) (CAdV-1) (Canine adenovirus 1
OS   (strain RI261)).
OC   Viruses; Varidnaviria; Bamfordvirae; Preplasmiviricota; Tectiliviricetes;
OC   Rowavirales; Adenoviridae; Mastadenovirus; Canine mastadenovirus A.
OX   NCBI_TaxID=69151;
OH   NCBI_TaxID=9615; Canis lupus familiaris (Dog) (Canis familiaris).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=9129661; DOI=10.1099/0022-1317-78-4-873;
RA   Morrison M.D., Onions D.E., Nicolson L.;
RT   "Complete DNA sequence of canine adenovirus type 1.";
RL   J. Gen. Virol. 78:873-878(1997).
CC   -!- FUNCTION: Major capsid protein that self-associates to form penton base
CC       pentamers, each in the shape of a pentagon, situated at the 12 vertices
CC       of the pseudo T=25 capsid. Involved in virus secondary attachment to
CC       host cell after initial attachment by the fiber protein, and in
CC       endocytosis of virions. As the virus enters the host cell, penton
CC       proteins are shed concomitant with virion acidification in the
CC       endosome. {ECO:0000255|HAMAP-Rule:MF_04052}.
CC   -!- SUBUNIT: Interacts with the fiber protein (via N-terminal tail region).
CC       Interacts with the capsid vertex protein; this interaction binds the
CC       penton base to neighboring peripentonal hexons. {ECO:0000255|HAMAP-
CC       Rule:MF_04052}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000255|HAMAP-Rule:MF_04052}. Host
CC       nucleus {ECO:0000255|HAMAP-Rule:MF_04052}. Note=Located at each vertex
CC       of the virion. {ECO:0000255|HAMAP-Rule:MF_04052}.
CC   -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC       {ECO:0000255|HAMAP-Rule:MF_04052}.
CC   -!- MISCELLANEOUS: All late proteins expressed from the major late promoter
CC       are produced by alternative splicing and alternative polyadenylation of
CC       the same gene giving rise to non-overlapping ORFs. A leader sequence is
CC       present in the N-terminus of all these mRNAs and is recognized by the
CC       viral shutoff protein to provide expression although conventional
CC       translation via ribosome scanning from the cap has been shut off in the
CC       host cell (By similarity). {ECO:0000250}.
CC   -!- MISCELLANEOUS: All late proteins expressed from the major late promoter
CC       are produced by alternative splicing and alternative polyadenylation of
CC       the same gene giving rise to non-overlapping ORFs. A leader sequence is
CC       present in the N-terminus of all these mRNAs and is recognized by the
CC       viral shutoff protein to provide expression although conventional
CC       translation via ribosome scanning from the cap has been shut off in the
CC       host cell. {ECO:0000255|HAMAP-Rule:MF_04052}.
CC   -!- SIMILARITY: Belongs to the adenoviridae penton family.
CC       {ECO:0000255|HAMAP-Rule:MF_04052}.
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DR   EMBL; Y07760; CAA69061.1; -; Genomic_DNA.
DR   RefSeq; AP_000054.1; AC_000003.1.
DR   RefSeq; NP_044193.1; NC_001734.1.
DR   SMR; P68947; -.
DR   GeneID; 1488926; -.
DR   KEGG; vg:1488926; -.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0039623; C:T=25 icosahedral viral capsid; IEA:UniProtKB-UniRule.
DR   GO; GO:0005198; F:structural molecule activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0075509; P:endocytosis involved in viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_04052; ADV_CAPSP; 1.
DR   InterPro; IPR002605; Adeno_Penton_B.
DR   Pfam; PF01686; Adeno_Penton_B; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Host nucleus; Host-virus interaction; Late protein;
KW   T=25 icosahedral capsid protein; Viral attachment to host cell;
KW   Viral penetration into host cytoplasm; Virion; Virus endocytosis by host;
KW   Virus entry into host cell.
FT   CHAIN           1..477
FT                   /note="Penton protein"
FT                   /id="PRO_0000221877"
SQ   SEQUENCE   477 AA;  53464 MW;  B9FDF37407D0FDA9 CRC64;
     MEFPSSPPPS YETVMAQVPS ILAPLVPPRY KGATEGRNSI RYSQLPPLFD TTKLYLIDNK
     SSDIQALNYQ NDHSNFLTTV VQNANYTPME ASTQSIQLDE RSRWGGDFRS ILHMNMPNVT
     EYMFSNSFKA YLPATADASG KVLTYEWYTL TIPEGNYSEV MLLDLLNNAV VENYLAHGRQ
     HNVKEEDIGL KFDTRNFYLG FDPETELVMP GFYTNEAFHP DIILSPGCAV DFTHSRLNNF
     LGIRKRLPYQ EGFIIKWEDL QGGNIPALLD LEIYNPDTPG DNITPLLQDS KARSYHVGED
     PSAGSTFTSY RSWFLAYNYG PVDGIKSKTV LVAPDITCGV EQIYWSLPDM AVDPVTFTSS
     HNPSSYPVVG TELLPLLPRS FYNGSSVYSQ LLQESTAQTH VFNRFPENAI LKRPPAPTII
     SISENVPALS NHGTLPLKNN IPGVQRVTIT DARRRVCPYV YKSLGVVVPR VLSSKTF