ID   Y1947_MYCTU             Reviewed;         303 AA.
AC   P9WFH7; L0T871; O07736; Q7D7T8;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 36.
DE   RecName: Full=Putative S-adenosyl-L-methionine-dependent methyltransferase Rv1896c;
DE            EC=2.1.1.-;
GN   OrderedLocusNames=Rv1896c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- FUNCTION: Exhibits S-adenosyl-L-methionine-dependent methyltransferase
CC       activity. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UPF0677 family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP44663.1; -; Genomic_DNA.
DR   PIR; E70517; E70517.
DR   RefSeq; NP_216412.1; NC_000962.3.
DR   RefSeq; WP_003409526.1; NZ_NVQJ01000013.1.
DR   AlphaFoldDB; P9WFH7; -.
DR   SMR; P9WFH7; -.
DR   STRING; 83332.Rv1896c; -.
DR   PaxDb; P9WFH7; -.
DR   DNASU; 885915; -.
DR   GeneID; 885915; -.
DR   KEGG; mtu:Rv1896c; -.
DR   TubercuList; Rv1896c; -.
DR   eggNOG; COG3315; Bacteria.
DR   OMA; GSAASMW; -.
DR   PhylomeDB; P9WFH7; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR011610; CHP00027_methylltransferase.
DR   InterPro; IPR007213; Ppm1/Ppm2/Tcmp.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   Pfam; PF04072; LCM; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   TIGRFAMs; TIGR00027; mthyl_TIGR00027; 1.
PE   1: Evidence at protein level;
KW   Methyltransferase; Reference proteome; S-adenosyl-L-methionine;
KW   Transferase.
FT   CHAIN           1..303
FT                   /note="Putative S-adenosyl-L-methionine-dependent
FT                   methyltransferase Rv1896c"
FT                   /id="PRO_0000361238"
FT   BINDING         129
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
FT   BINDING         158..159
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   303 AA;  33267 MW;  7480EB8065C70DA8 CRC64;
     MTTPEYGSLR SDDDHWDIVS NVGYTALLVA GWRALHTTGP KPLVQDEYAK HFITASADPY
     LEGLLANPRT SEDGTAFPRL YGVQTRFFDD FFNCADEAGI RQAVIVAAGL DCRAYRLDWQ
     PGTTVFEIDV PKVLEFKARV LSERGAVPKA HRVAVPADLR TDWPTPLTAA GFDPQRPSAW
     SVEGLLPYLT GDAQYALFAR IDELCAPGSR VALGALGSRL DHEQLAALET AHPGVNMSGD
     VNFSALTYDD KTDPVEWLVE HGWAVDPVRS TLELQVGYGL TPPDVDVKID SFMRSQYITA
     VRA