ID   CAPSP_ADEG1             Reviewed;         515 AA.
AC   Q64755;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   02-JUN-2021, entry version 68.
DE   RecName: Full=Penton protein {ECO:0000255|HAMAP-Rule:MF_04052};
DE            Short=CP-P {ECO:0000255|HAMAP-Rule:MF_04052};
DE   AltName: Full=Penton base protein {ECO:0000255|HAMAP-Rule:MF_04052};
DE   AltName: Full=Protein III {ECO:0000255|HAMAP-Rule:MF_04052};
GN   Name=L2 {ECO:0000255|HAMAP-Rule:MF_04052};
OS   Fowl adenovirus A serotype 1 (strain CELO / Phelps) (FAdV-1) (Avian
OS   adenovirus gal1 (strain Phelps)).
OC   Viruses; Varidnaviria; Bamfordvirae; Preplasmiviricota; Tectiliviricetes;
OC   Rowavirales; Adenoviridae; Aviadenovirus; Fowl aviadenovirus A.
OX   NCBI_TaxID=10553;
OH   NCBI_TaxID=8976; Galliformes.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8634026; DOI=10.1007/bf01718405;
RA   Akopian T.A., Lazareva S.E., Tikhomirov E.E., Karpov V.A., Naroditsky B.S.;
RT   "Genes for fowl adenovirus CELO penton base and core polypeptides.";
RL   Arch. Virol. 141:357-365(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=8627769; DOI=10.1128/jvi.70.5.2939-2949.1996;
RA   Chiocca S., Kurzbauer R., Schaffner G., Baker A., Mautner V., Cotten M.;
RT   "The complete DNA sequence and genomic organization of the avian adenovirus
RT   CELO.";
RL   J. Virol. 70:2939-2949(1996).
CC   -!- FUNCTION: Major capsid protein that self-associates to form penton base
CC       pentamers, each in the shape of a pentagon, situated at the 12 vertices
CC       of the pseudo T=25 capsid. Involved in virus secondary attachment to
CC       host cell after initial attachment by the fiber protein, and in
CC       endocytosis of virions. As the virus enters the host cell, penton
CC       proteins are shed concomitant with virion acidification in the
CC       endosome. {ECO:0000255|HAMAP-Rule:MF_04052}.
CC   -!- SUBUNIT: Interacts with the fiber protein (via N-terminal tail region).
CC       Interacts with the capsid vertex protein; this interaction binds the
CC       penton base to neighboring peripentonal hexons. {ECO:0000255|HAMAP-
CC       Rule:MF_04052}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000255|HAMAP-Rule:MF_04052}. Host
CC       nucleus {ECO:0000255|HAMAP-Rule:MF_04052}. Note=Located at each vertex
CC       of the virion. {ECO:0000255|HAMAP-Rule:MF_04052}.
CC   -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC       {ECO:0000255|HAMAP-Rule:MF_04052}.
CC   -!- MISCELLANEOUS: All late proteins expressed from the major late promoter
CC       are produced by alternative splicing and alternative polyadenylation of
CC       the same gene giving rise to non-overlapping ORFs. A leader sequence is
CC       present in the N-terminus of all these mRNAs and is recognized by the
CC       viral shutoff protein to provide expression although conventional
CC       translation via ribosome scanning from the cap has been shut off in the
CC       host cell. {ECO:0000255|HAMAP-Rule:MF_04052}.
CC   -!- SIMILARITY: Belongs to the adenoviridae penton family.
CC       {ECO:0000255|HAMAP-Rule:MF_04052}.
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DR   EMBL; U46933; AAC54908.1; -; Genomic_DNA.
DR   RefSeq; NP_043882.1; NC_001720.1.
DR   SMR; Q64755; -.
DR   GeneID; 1476561; -.
DR   KEGG; vg:1476561; -.
DR   Proteomes; UP000001594; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0039623; C:T=25 icosahedral viral capsid; IEA:UniProtKB-UniRule.
DR   GO; GO:0005198; F:structural molecule activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0075509; P:endocytosis involved in viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_04052; ADV_CAPSP; 1.
DR   InterPro; IPR002605; Adeno_Penton_B.
DR   Pfam; PF01686; Adeno_Penton_B; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Host nucleus; Host-virus interaction; Late protein;
KW   Reference proteome; T=25 icosahedral capsid protein;
KW   Viral attachment to host cell; Viral penetration into host cytoplasm;
KW   Virion; Virus endocytosis by host; Virus entry into host cell.
FT   CHAIN           1..515
FT                   /note="Penton protein"
FT                   /id="PRO_0000221879"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        7..25
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   515 AA;  56722 MW;  90C389ACD686C6AC CRC64;
     MYRSLRPPTS IPPPPPSGPS PYPAMINGYP PDVPVGSPAN GDAELFVPLQ RVMPPTGGRN
     SIRYRNYAPC QNTTKFFYVD NKLSDLDTYN EDANHSNFRT TVIHNQDLDP STAATETIQL
     DNRSCWGGEL KTAVKTNCPN ISSFFQSDTV RVRLMSKRDP GGTDPDAGVN NPPGAEYKWY
     DLRIPEGNYA LNEIIDLLNE GIVQLYLQEG RQNNVLKSDI GVKFDTRYLD LLKDPVTGLV
     TPGTYVYKGY HPDIILLPGC AVDFTFSRLS LLLGIAKREP YSKGFTITYE DLQGGNVPAL
     LDLSSVQVDD QDEDVIVVAD ARPLLKDSKG VSYNVITTGV TQPQTAYRSW LLAYHTLDSP
     ARNKTLLTVP DMAGGIGAMY TSMPDTFTAP AGFKEDNTTN LCPVVAMNLF PSFNKVFYQG
     ASAYVQRLEN ATQSATAAFN RFPENEILKQ APPMNVSSVC DNQPAVVQQG VLPLKNSLSG
     LQRVLITDDR RRPIPYVYKT IATVQPRVLS SSTLQ