ID   Y1959_MYCS2             Reviewed;        1003 AA.
AC   A0QTT7; I7FZ65;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=UPF0182 protein MSMEG_1959/MSMEI_1915 {ECO:0000255|HAMAP-Rule:MF_01600};
GN   OrderedLocusNames=MSMEG_1959, MSMEI_1915;
OS   Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium
OS   smegmatis).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycolicibacterium.
OX   NCBI_TaxID=246196;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700084 / mc(2)155;
RA   Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C.,
RA   Fraser C.M.;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700084 / mc(2)155;
RX   PubMed=17295914; DOI=10.1186/gb-2007-8-2-r20;
RA   Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C.,
RA   Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.;
RT   "Interrupted coding sequences in Mycobacterium smegmatis: authentic
RT   mutations or sequencing errors?";
RL   Genome Biol. 8:R20.1-R20.9(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND IDENTIFICATION BY MASS
RP   SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 700084 / mc(2)155;
RX   PubMed=18955433; DOI=10.1101/gr.081901.108;
RA   Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M.,
RA   Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.;
RT   "Ortho-proteogenomics: multiple proteomes investigation through orthology
RT   and a new MS-based protocol.";
RL   Genome Res. 19:128-135(2009).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01600};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01600}.
CC   -!- SIMILARITY: Belongs to the UPF0182 family. {ECO:0000255|HAMAP-
CC       Rule:MF_01600}.
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DR   EMBL; CP000480; ABK69686.1; -; Genomic_DNA.
DR   EMBL; CP001663; AFP38387.1; -; Genomic_DNA.
DR   RefSeq; WP_011728043.1; NZ_SIJM01000020.1.
DR   RefSeq; YP_886325.1; NC_008596.1.
DR   AlphaFoldDB; A0QTT7; -.
DR   SMR; A0QTT7; -.
DR   STRING; 246196.MSMEI_1915; -.
DR   PRIDE; A0QTT7; -.
DR   EnsemblBacteria; ABK69686; ABK69686; MSMEG_1959.
DR   EnsemblBacteria; AFP38387; AFP38387; MSMEI_1915.
DR   GeneID; 66733389; -.
DR   KEGG; msg:MSMEI_1915; -.
DR   KEGG; msm:MSMEG_1959; -.
DR   PATRIC; fig|246196.19.peg.1937; -.
DR   eggNOG; COG1615; Bacteria.
DR   OMA; HLRYPQD; -.
DR   OrthoDB; 170146at2; -.
DR   Proteomes; UP000000757; Chromosome.
DR   Proteomes; UP000006158; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   HAMAP; MF_01600; UPF0182; 1.
DR   InterPro; IPR005372; UPF0182.
DR   PANTHER; PTHR39344; PTHR39344; 1.
DR   Pfam; PF03699; UPF0182; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..1003
FT                   /note="UPF0182 protein MSMEG_1959/MSMEI_1915"
FT                   /id="PRO_1000088008"
FT   TRANSMEM        18..38
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        63..83
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        114..134
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        176..196
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        211..231
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        260..280
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        288..308
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   REGION          902..960
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        934..949
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1003 AA;  109093 MW;  65268EA87D589214 CRC64;
     MGMRPTARMP KLTRRSRVLI AFALVAVLLL LLGPRLIDTY VDWLWFGELG YRSVFTTVLA
     TRLIVFVVVA LAIGAIVFAG LALAYRTRPV FVPTAGPNDP VARYRTTVMA RLRLFGIGVP
     VFIGLLAGIV AQSYWVKIQL FLHGGDFGIT DPEFGKDLGF YAFDLPFYRL VLTYLFVATF
     LAFVANLLGH YLFGGIRLTG RVGALSRAAR IQLISLAGTL IVLKAFAYWL DRYELLSNDR
     SAKPFTGAGY TDINAVLPAK LIMLAIAVIC AVAVFSALVL RDLRIPAIGV ALLLLSSLVV
     GAGWPLIVEQ FSVKPNAAQK EAEYISRSIE ATRHAYGLTD ETVTYRNYEN TGQTTAAQVA
     ADRATTSNIR LLDPTIVSPA FTQFQQGKNF YYFPDQLSID RYIGPDGNLR DYVVAARELN
     PDRLIDNQRD WINRHTVYTH GNGFIASPAN TVRGVANDPN QNGGYPEFLA SVVGANGSVI
     SPGPAPLDQP RIYFGPVISN TPADYAIVGK TGDTDREYDY ETNTETKNYT YGGKGGVPIG
     NWLNRSVFAA KFAERNFLFS NVIGENSKIL FNRDPAERVE AVAPWLTTDT SVYPAIVNKR
     MVWIVDGYTT LDNYPYSELT TLSSATADSN EVAVNRLAPD KKVSYIRNSV KATVDAYDGT
     VTLYAQDEND PVLKAWMDVF PGTVKPKADI TPELQAHLRY PEDLFKVQRA LLAKYHVDNP
     VTFFSAQDFW DVPLDPNPTA SSFQPPYYIV AKDLVKNDNS ASFQLTSALN RFQRDFLAAY
     VSASSDPETY GKLTVLTIPG QVNGPKLAFN AISTDTAVSQ DLGVIGRDNQ NRIRWGNLLT
     LPVADGGLLY VAPVYASPGS SDAASSYPRL IRVAMLYNDR VGYGPTVSDA LTELFGPGAG
     ATATDVAPAE GRPAQSTPNG QQPAASPPPA ANADGRPAQA PPPPSAATPT GPVQISQAKA
     EALQDLESAL TAAQEAQRSG DFAEYGQALQ RLNDAMKKYD SAK