Y195A_HAEIN
ID Y195A_HAEIN Reviewed; 1111 AA.
AC Q57362;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Uncharacterized MscS family protein HI_0195.1;
DE Flags: Precursor;
GN OrderedLocusNames=HI_0195.1;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY.
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=10675023;
RX DOI=10.1002/(sici)1522-2683(20000101)21:2<411::aid-elps411>3.0.co;2-4;
RA Langen H., Takacs B., Evers S., Berndt P., Lahm H.W., Wipf B., Gray C.,
RA Fountoulakis M.;
RT "Two-dimensional map of the proteome of Haemophilus influenzae.";
RL Electrophoresis 21:411-429(2000).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the MscS (TC 1.A.23) family. {ECO:0000305}.
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DR EMBL; L42023; AAC21864.1; -; Genomic_DNA.
DR RefSeq; NP_438364.1; NC_000907.1.
DR AlphaFoldDB; Q57362; -.
DR SMR; Q57362; -.
DR STRING; 71421.HI_0195.1; -.
DR EnsemblBacteria; AAC21864; AAC21864; HI_0195.1.
DR KEGG; hin:HI_0195.1; -.
DR PATRIC; fig|71421.8.peg.200; -.
DR eggNOG; COG3096; Bacteria.
DR eggNOG; COG3264; Bacteria.
DR HOGENOM; CLU_007829_3_0_6; -.
DR OMA; YWVWSDL; -.
DR PhylomeDB; Q57362; -.
DR BioCyc; HINF71421:G1GJ1-206-MON; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0009992; P:cellular water homeostasis; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 2.30.30.60; -; 1.
DR InterPro; IPR010920; LSM_dom_sf.
DR InterPro; IPR006685; MscS_channel.
DR InterPro; IPR011066; MscS_channel_C.
DR InterPro; IPR006686; MscS_channel_CS.
DR InterPro; IPR011014; MscS_channel_TM-2.
DR InterPro; IPR023408; MscS_dom_sf.
DR InterPro; IPR025692; MscS_IM_dom1.
DR InterPro; IPR024393; MscS_porin.
DR Pfam; PF00924; MS_channel; 1.
DR Pfam; PF12795; MscS_porin; 1.
DR Pfam; PF12794; MscS_TM; 1.
DR SUPFAM; SSF50182; SSF50182; 1.
DR SUPFAM; SSF82689; SSF82689; 1.
DR SUPFAM; SSF82861; SSF82861; 1.
DR PROSITE; PS01246; UPF0003; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..31
FT /evidence="ECO:0000255"
FT CHAIN 32..1111
FT /note="Uncharacterized MscS family protein HI_0195.1"
FT /id="PRO_0000036181"
FT TRANSMEM 490..510
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 538..558
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 572..592
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 620..640
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 644..664
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 694..714
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 797..817
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 840..860
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 885..905
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 922..942
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1003..1023
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1111 AA; 126826 MW; 15DF8F9F7E4E701C CRC64;
MIRKLMKIPP FFTALFASAM FTLSVSQGVL AANSTNVLPT EQSLKADLAN AQKMSEGEAK
NRLLAELQTS IDLLQQIQAQ QKINDALQTT LSHSESEIRK NNAEIQALKK QQETATSTDD
NAQSQDYLQN SLTKLNDQLQ DTQNALSTAN AQLAGQSSIS ERAQAALTEN VVRTQQINQQ
LANNDIGSTL RKQYQIDLQL IDLKNSYNQN LLKNNDQLSL LYQSRYNLLN LRLQVQQQNI
IAIQEVINQK NLQQSQNQVE QAQQQQKTVQ NDYIQKELDR NAQLGQYLLQ QTEKANSLTQ
DELRMRNILD SLTQTQRTID EQISALQGTL VLSRIIQQQK QKLPTNLNIQ GLSKQIADLR
VHIFDITQKR NELYDLDNYI NKVESEDGKQ FTEAERTQVK TLLTERRKMT SDLIKSLNNQ
LNLAISLELT QLQITQISDQ IQSKLEQQSF WVKSNNPINL DWVKMLPRAL IEQFNGMLKK
LGFPTNYDNL PYLLMYFLGL FIVGGAIFKF KNRIKQQLNK INREIHRLDT DSQWSTPLAL
LLTAFLTLSS TLWFLAVCQM IGFFFFKNPE EFWHWSFSMA GYWWFFTFWI SLFRPNGIFV
NHFESSKENA QRFRGVIQRI IVVVVLLLNT SVFSNVTDAG LANDVLGQIN TIAALIFCAA
IIAPRFNRVL RSYEPETNKH HWLIRIVQIG FRLIPVGLIV LIVLGYYYTA LNLIEHFIHS
YIAWCVWWLV RNTIYRGITV SSRRLAHRRL AEKRRQKALE NNYENISSDD VVAVGEPEES
LALNDVRSQL LRFVDLFIWT ALLGIFYYVW SDLVTVVSYL REITLWQQTT TTDAGTVMES
ITLFNLLVAL VIVGITYVLV RNISGILEVL IFSRVNLSQG TPYTITTLLT YIFIAIGGAW
AFATLGMSWS KLQWLFAALS VGLGFGMQEI FANFVSGIIL LFERPIRVGD VVTINEVSGT
VAKIRIRAIT LIDFDRKEVI VPNKSFVTGQ VTNWALSNTM TRLVISVGVA YGSDLTLVRQ
LLLQAADEQP TILRDPKPSA YFLTFGASTL DHELRVYVEQ VGDRTSTTDA LNRRINELFA
EHNIDIAFNQ LDVFIKNNDT GEEIPFVDVK K
