ID   Y196_MYCTU              Reviewed;         194 AA.
AC   P9WME1; L0T2T3; O53647; Q7DAA6;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 41.
DE   RecName: Full=Uncharacterized HTH-type transcriptional regulator Rv0196;
GN   OrderedLocusNames=Rv0196;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION AS A DRUG TARGET [LARGE SCALE ANALYSIS].
RX   PubMed=19099550; DOI=10.1186/1752-0509-2-109;
RA   Raman K., Yeturu K., Chandra N.;
RT   "targetTB: a target identification pipeline for Mycobacterium tuberculosis
RT   through an interactome, reactome and genome-scale structural analysis.";
RL   BMC Syst. Biol. 2:109-109(2008).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- MISCELLANEOUS: Was identified as a high-confidence drug target.
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DR   EMBL; AL123456; CCP42924.1; -; Genomic_DNA.
DR   PIR; A70838; A70838.
DR   RefSeq; NP_214710.1; NC_000962.3.
DR   RefSeq; WP_003401168.1; NZ_NVQJ01000001.1.
DR   AlphaFoldDB; P9WME1; -.
DR   SMR; P9WME1; -.
DR   STRING; 83332.Rv0196; -.
DR   PaxDb; P9WME1; -.
DR   DNASU; 886760; -.
DR   GeneID; 886760; -.
DR   KEGG; mtu:Rv0196; -.
DR   TubercuList; Rv0196; -.
DR   eggNOG; COG1309; Bacteria.
DR   OMA; FQLQGYY; -.
DR   PhylomeDB; P9WME1; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProt.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001647; HTH_TetR.
DR   InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR   Pfam; PF00440; TetR_N; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF48498; SSF48498; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..194
FT                   /note="Uncharacterized HTH-type transcriptional regulator
FT                   Rv0196"
FT                   /id="PRO_0000382632"
FT   DOMAIN          2..62
FT                   /note="HTH tetR-type"
FT   DNA_BIND        25..44
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   194 AA;  21241 MW;  CDB2854C0DCC41F0 CRC64;
     MQGPRERMVV SAALLIRERG AHATAISDVL QHSGAPRGSA YHYFPGGRTQ LLCEAVDYAG
     EHVAAMINEA EGGLELLDAL IDKYRQQLLS TDFRAGCPIA AVSVEAGDEQ DRERMAPVIA
     RAAAVFDRWS DLTAQRFIAD GIPPDRAHEL AVLATSTLEG AILLARVRRD LTPLDLVHRQ
     LRNLLLAELP ERSR