ID   Y1980_VIBPA             Reviewed;         777 AA.
AC   Q87N95;
DT   24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=UPF0313 protein VP1980 {ECO:0000255|HAMAP-Rule:MF_01251};
GN   OrderedLocusNames=VP1980;
OS   Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=223926;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RIMD 2210633;
RX   PubMed=12620739; DOI=10.1016/s0140-6736(03)12659-1;
RA   Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K.,
RA   Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S.,
RA   Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T.;
RT   "Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism
RT   distinct from that of V. cholerae.";
RL   Lancet 361:743-749(2003).
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01251};
CC       Note=Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3
CC       cysteines and an exchangeable S-adenosyl-L-methionine.
CC       {ECO:0000255|HAMAP-Rule:MF_01251};
CC   -!- SIMILARITY: Belongs to the UPF0313 family. {ECO:0000255|HAMAP-
CC       Rule:MF_01251}.
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DR   EMBL; BA000031; BAC60243.1; -; Genomic_DNA.
DR   RefSeq; NP_798359.1; NC_004603.1.
DR   RefSeq; WP_005481673.1; NC_004603.1.
DR   AlphaFoldDB; Q87N95; -.
DR   STRING; 223926.28806972; -.
DR   EnsemblBacteria; BAC60243; BAC60243; BAC60243.
DR   GeneID; 1189491; -.
DR   KEGG; vpa:VP1980; -.
DR   PATRIC; fig|223926.6.peg.1893; -.
DR   eggNOG; COG1032; Bacteria.
DR   HOGENOM; CLU_018288_2_0_6; -.
DR   OMA; TCMYYTG; -.
DR   Proteomes; UP000002493; Chromosome 1.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.80.30.20; -; 1.
DR   HAMAP; MF_01251; UPF0313; 1.
DR   InterPro; IPR006638; Elp3/MiaB/NifB.
DR   InterPro; IPR020612; Methylthiotransferase_CS.
DR   InterPro; IPR007197; rSAM.
DR   InterPro; IPR023404; rSAM_horseshoe.
DR   InterPro; IPR022946; UPF0313.
DR   InterPro; IPR024560; UPF0313_C.
DR   InterPro; IPR013704; UPF0313_N.
DR   PANTHER; PTHR32331; PTHR32331; 1.
DR   Pfam; PF11842; DUF3362; 1.
DR   Pfam; PF04055; Radical_SAM; 1.
DR   Pfam; PF08497; Radical_SAM_N; 1.
DR   SFLD; SFLDS00029; Radical_SAM; 1.
DR   SFLD; SFLDG01069; UPF0313; 1.
DR   SMART; SM00729; Elp3; 1.
DR   TIGRFAMs; TIGR03904; SAM_YgiQ; 1.
DR   PROSITE; PS51918; RADICAL_SAM; 1.
PE   3: Inferred from homology;
KW   4Fe-4S; Iron; Iron-sulfur; Metal-binding; Reference proteome;
KW   S-adenosyl-L-methionine.
FT   CHAIN           1..777
FT                   /note="UPF0313 protein VP1980"
FT                   /id="PRO_0000076399"
FT   DOMAIN          363..642
FT                   /note="Radical SAM core"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01266"
FT   REGION          675..777
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        720..761
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         377
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_note="4Fe-4S-S-AdoMet"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01251"
FT   BINDING         381
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_note="4Fe-4S-S-AdoMet"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01251"
FT   BINDING         384
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_note="4Fe-4S-S-AdoMet"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01251"
SQ   SEQUENCE   777 AA;  87107 MW;  60D34D0DF08289FF CRC64;
     MTNNITPIHE YKKYWAECFG TAPFLPTSRK EMDALGWDSC DIIIVTGDAY VDHPSFGMAI
     IGRLLEAQGF RVGIIAQPEW QNKNAFMQLG KPNLFFGITA GNMDSMINRY TADKKLRHDD
     AYTPNNEGGK RPDRATLVYS QRCREAYKEV PIVLGGIEAS LRRVAHYDYW SDKVRRSVLF
     DAKADILLFG NAERALVEVA HRIANGEDIS TMTNIRGTAV NLPAAPEGYT VIDSSRIEKP
     RKEAFVPKNP YEVETQCETK KDEPVAQPIT IRPSRHDAAT TAVRLPSFEK LRNDRILYAH
     ASRVLHLETN PYSGRALLQS HGDRELWVNQ APIPLTTEEM DFVFGLPYAR VPHPMYGKAK
     IPAYDMIKTS VNIMRGCFGG CSFCSITEHE GRIIQNRSKE SIINEIEEIR DKVPGFTGTI
     SDLGGPTANM YRLGCKDPKA EANCRRPSCV FPGICNKLNT DHKHTIDLYR EARKVEGVKK
     VMVASGVRYD LAIESPEYVK ELVTHHVGGY LKIAPEHTEK GPLDLMMKPG MGTYDRFKEM
     FEKYSAEAGK KQYLIPYFIS AHPGTEDEDM LNLALWLKKN NFECDQVQNF YPSPMCNATS
     MYYSETNPLK RVKYKQREDI PVAKGERQRR LHKALLRYHD PANWPLIREA LINMGKKHLI
     GDKPTCLVPA EDIDAQTPAQ RRKSGRHGAN RFATKHTKNQ PGFGGHLNKR AEGGSKDGKP
     SGNRNGSGKV QGGQRPASNG QRPSGNGANR PAGSKPQGQG RPQGQGKPAG QRKPKRR