ID   Y1985_MYCSK             Reviewed;         276 AA.
AC   A1UEC6;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Uncharacterized oxidoreductase Mkms_1985;
DE            EC=1.-.-.-;
GN   OrderedLocusNames=Mkms_1985;
OS   Mycobacterium sp. (strain KMS).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; unclassified Mycobacterium.
OX   NCBI_TaxID=189918;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KMS;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Miller C.D.,
RA   Richardson P.;
RT   "Complete sequence of chromosome of Mycobacterium sp. KMS.";
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the aldo/keto reductase family. {ECO:0000305}.
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DR   EMBL; CP000518; ABL91184.1; -; Genomic_DNA.
DR   RefSeq; WP_011768182.1; NC_008705.1.
DR   AlphaFoldDB; A1UEC6; -.
DR   SMR; A1UEC6; -.
DR   STRING; 189918.Mkms_1985; -.
DR   EnsemblBacteria; ABL91184; ABL91184; Mkms_1985.
DR   KEGG; mkm:Mkms_1985; -.
DR   HOGENOM; CLU_023205_0_1_11; -.
DR   OMA; AEMYANE; -.
DR   OrthoDB; 1035565at2; -.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.20.20.100; -; 1.
DR   InterPro; IPR020471; AKR.
DR   InterPro; IPR018170; Aldo/ket_reductase_CS.
DR   InterPro; IPR023210; NADP_OxRdtase_dom.
DR   InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR   PANTHER; PTHR43827; PTHR43827; 1.
DR   Pfam; PF00248; Aldo_ket_red; 1.
DR   PIRSF; PIRSF000097; AKR; 1.
DR   PRINTS; PR00069; ALDKETRDTASE.
DR   SUPFAM; SSF51430; SSF51430; 1.
DR   PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
DR   PROSITE; PS00063; ALDOKETO_REDUCTASE_3; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase.
FT   CHAIN           1..276
FT                   /note="Uncharacterized oxidoreductase Mkms_1985"
FT                   /id="PRO_0000380745"
FT   REGION          257..276
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        50
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000250"
FT   BINDING         108
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         188..240
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   276 AA;  30161 MW;  830D19D03CA5B028 CRC64;
     MGAPLVALND GNSIPQVGLG VWQTPPEDTE RAVAAALAAG YRHVDTAAAY GNEEQTGRAI
     AQSGLDRSQV YLVTKLWNSE QGYDATLAAF EASVDRLGVD YLDLYLIHWP VPEKNLFVDT
     FKAFARLRED GRIRSIGVSN FEPEHLRVLI DSTGIVPAVN QIELHPLLPQ RELRELHAQL
     GIATEAWSPL GQGSLLAHPT VTGVAESHGK TAAQALIRWH MQLGNIVIPK SVNPQRIESN
     FDVFDFELSE QDMASISSLE DGSRLGPDPK TFNFTG