ID   Y1991_PASMU             Reviewed;         442 AA.
AC   Q9CJL2;
DT   15-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=Putative zinc metalloprotease PM1991;
DE            EC=3.4.24.-;
GN   OrderedLocusNames=PM1991;
OS   Pasteurella multocida (strain Pm70).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Pasteurella.
OX   NCBI_TaxID=272843;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Pm70;
RX   PubMed=11248100; DOI=10.1073/pnas.051634598;
RA   May B.J., Zhang Q., Li L.L., Paustian M.L., Whittam T.S., Kapur V.;
RT   "Complete genomic sequence of Pasteurella multocida Pm70.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:3460-3465(2001).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000305};
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peptidase M50B family. {ECO:0000305}.
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DR   EMBL; AE004439; AAK04075.1; -; Genomic_DNA.
DR   RefSeq; WP_010907438.1; NC_002663.1.
DR   AlphaFoldDB; Q9CJL2; -.
DR   SMR; Q9CJL2; -.
DR   STRING; 747.DR93_2108; -.
DR   EnsemblBacteria; AAK04075; AAK04075; PM1991.
DR   KEGG; pmu:PM1991; -.
DR   PATRIC; fig|272843.6.peg.2014; -.
DR   HOGENOM; CLU_025778_0_2_6; -.
DR   OMA; QYMVGFG; -.
DR   Proteomes; UP000000809; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.42.10; -; 2.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR004387; Pept_M50_Zn.
DR   InterPro; IPR008915; Peptidase_M50.
DR   PANTHER; PTHR42837; PTHR42837; 2.
DR   Pfam; PF00595; PDZ; 1.
DR   Pfam; PF02163; Peptidase_M50; 1.
DR   SMART; SM00228; PDZ; 2.
DR   SUPFAM; SSF50156; SSF50156; 2.
DR   TIGRFAMs; TIGR00054; TIGR00054; 1.
DR   PROSITE; PS00142; ZINC_PROTEASE; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Hydrolase; Membrane; Metal-binding;
KW   Metalloprotease; Protease; Reference proteome; Transmembrane;
KW   Transmembrane helix; Zinc.
FT   CHAIN           1..442
FT                   /note="Putative zinc metalloprotease PM1991"
FT                   /id="PRO_0000088452"
FT   TRANSMEM        97..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        366..388
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        418..440
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          198..286
FT                   /note="PDZ"
FT   ACT_SITE        22
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10095"
FT   BINDING         21
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10095"
FT   BINDING         25
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10095"
SQ   SEQUENCE   442 AA;  48609 MW;  915E65C99AD4E150 CRC64;
     MSFLWSFASF IIVISVLVAV HEYGHFWAAR KCGIQVHRFS IGFGKVLWSR TDKQGTEFVI
     SAIPLGGYVK MLDGRNEVVP PELSSRAFDQ KSVLQRAFVI AAGPIANFLF AILAYFTIYT
     VGIPTVKPVI ADISSNSIAA QAQIEPNTQI MAVDGTKVSD WETINMLLAT KMGNDEIHLT
     LSPFGSSIEQ HKVLNTKDWR FDPEKESAMS SLGLQPVRTK VDMILSKVEV NSPADKAGLK
     AGDRIYAGEQ LISWQQFVQF VQEGKPFNVK VERDGQFSFV VLTPELNKKG RWYVGIAPTA
     APISDIYRTE LKYGILEALQ KGVEKTIQLS WLTIKVIGKL FTGDLALKNL GGPISIAKGA
     GISSEIGLIY YLGFMALISV NLGIMNLFPL PVLDGGHLVF LAAEAVRGKP LSERIQNLSY
     RIGAAILMAL MGFALFNDFL RL