ID   Y1998_MYCTU             Reviewed;         258 AA.
AC   P9WLN9; L0TB19; Q10859;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 35.
DE   RecName: Full=Uncharacterized protein Rv1998c;
GN   OrderedLocusNames=Rv1998c; ORFNames=MTCY39.20;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   INDUCTION BY HYPOXIA.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=11416222; DOI=10.1073/pnas.121172498;
RA   Sherman D.R., Voskuil M., Schnappinger D., Liao R., Harrell M.I.,
RA   Schoolnik G.K.;
RT   "Regulation of the Mycobacterium tuberculosis hypoxic response gene
RT   encoding alpha -crystallin.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:7534-7539(2001).
RN   [3]
RP   INDUCTION BY NITRIC OXIDE (NO) AND BY HYPOXIA, AND DORMANCY REGULON.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=12953092; DOI=10.1084/jem.20030205;
RA   Voskuil M.I., Schnappinger D., Visconti K.C., Harrell M.I., Dolganov G.M.,
RA   Sherman D.R., Schoolnik G.K.;
RT   "Inhibition of respiration by nitric oxide induces a Mycobacterium
RT   tuberculosis dormancy program.";
RL   J. Exp. Med. 198:705-713(2003).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- INDUCTION: A member of the dormancy regulon. Induced in response to
CC       reduced oxygen tension (hypoxia) and low levels of nitric oxide (NO).
CC       It is hoped that this regulon will give insight into the latent, or
CC       dormant phase of infection. {ECO:0000269|PubMed:11416222,
CC       ECO:0000269|PubMed:12953092}.
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DR   EMBL; AL123456; CCP44770.1; -; Genomic_DNA.
DR   PIR; D70758; D70758.
DR   RefSeq; NP_216514.1; NC_000962.3.
DR   RefSeq; WP_003899122.1; NZ_NVQJ01000043.1.
DR   AlphaFoldDB; P9WLN9; -.
DR   SMR; P9WLN9; -.
DR   STRING; 83332.Rv1998c; -.
DR   PaxDb; P9WLN9; -.
DR   DNASU; 888853; -.
DR   GeneID; 888853; -.
DR   KEGG; mtu:Rv1998c; -.
DR   TubercuList; Rv1998c; -.
DR   eggNOG; COG2513; Bacteria.
DR   OMA; PNAWDHA; -.
DR   PhylomeDB; P9WLN9; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   CDD; cd00377; ICL_PEPM; 1.
DR   Gene3D; 3.20.20.60; -; 1.
DR   InterPro; IPR039556; ICL/PEPM.
DR   InterPro; IPR015813; Pyrv/PenolPyrv_Kinase-like_dom.
DR   InterPro; IPR040442; Pyrv_Kinase-like_dom_sf.
DR   SUPFAM; SSF51621; SSF51621; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..258
FT                   /note="Uncharacterized protein Rv1998c"
FT                   /id="PRO_0000103926"
SQ   SEQUENCE   258 AA;  27253 MW;  BA89B3FDB51D9E5E CRC64;
     MSFHDLHHQG VPFVLPNAWD VPSALAYLAE GFTAIGTTSF GVSSSGGHPD GHRATRGANI
     ALAAALAPLQ CYVSVDIEDG YSDEPDAIAD YVAQLSTAGI NIEDSSAEKL IDPALAAAKI
     VAIKQRNPEV FVNARVDTYW LRQHADTTST IQRALRYVDA GADGVFVPLA NDPDELAELT
     RNIPCPVNTL PVPGLTIADL GELGVARVST GSVPYSAGLY AAAHAARAVS DGEQLPRSVP
     YAELQARLVD YENRTSTT