ID   Y1999_MYCTU             Reviewed;         440 AA.
AC   P9WQM3; L0T9W4; P63349; Q10858;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 39.
DE   RecName: Full=Uncharacterized transporter Rv1999c;
GN   OrderedLocusNames=Rv1999c; ORFNames=MTCY39.19;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- FUNCTION: Probable amino-acid or metabolite transport protein.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC       superfamily. {ECO:0000305}.
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DR   EMBL; AL123456; CCP44771.1; -; Genomic_DNA.
DR   PIR; E70758; E70758.
DR   RefSeq; NP_216515.1; NC_000962.3.
DR   RefSeq; WP_003410039.1; NZ_NVQJ01000043.1.
DR   AlphaFoldDB; P9WQM3; -.
DR   SMR; P9WQM3; -.
DR   STRING; 83332.Rv1999c; -.
DR   PaxDb; P9WQM3; -.
DR   DNASU; 888881; -.
DR   GeneID; 888881; -.
DR   KEGG; mtu:Rv1999c; -.
DR   TubercuList; Rv1999c; -.
DR   eggNOG; COG0531; Bacteria.
DR   OMA; RDRHLPH; -.
DR   PhylomeDB; P9WQM3; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR002293; AA/rel_permease1.
DR   Pfam; PF13520; AA_permease_2; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..440
FT                   /note="Uncharacterized transporter Rv1999c"
FT                   /id="PRO_0000054227"
FT   TRANSMEM        24..44
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        47..67
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        93..113
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        117..137
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        155..175
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        183..203
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        229..249
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        276..296
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        323..343
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        346..366
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        379..399
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        400..420
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   440 AA;  45267 MW;  9592EE0A842D18CD CRC64;
     MRRPLDPRDI PDELRRRLGL LDAVVIGLGS MIGAGIFAAL APAAYAAGSG LLLGLAVAAV
     VAYCNAISSA RLAARYPASG GTYVYGRMRL GDFWGYLAGW GFVVGKTASC AAMALTVGFY
     VWPAQAHAVA VAVVVALTAV NYAGIQKSAW LTRSIVAVVL VVLTAVVVAA YGSGAADPAR
     LDIGVDAHVW GMLQAAGLLF FAFAGYARIA TLGEEVRDPA RTIPRAIPLA LGITLAVYAL
     VAVAVIAVLG PQRLARAAAP LSEAMRVAGV NWLIPVVQIG AAVAALGSLL ALILGVSRTT
     LAMARDRHLP RWLAAVHPRF KVPFRAELVV GAVVAALAAT ADIRGAIGFS SFGVLVYYAI
     ANASALTLGL DEGRPRRLIP LVGLIGCVVL AFALPLSSVA AGAAVLGVGV AAYGVRRIIT
     RRARQTDSGD TQRSGHPSAT