ID   Y2003_MYCTO             Reviewed;         285 AA.
AC   P9WJZ4; L0TB26; P64919; Q10853;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 32.
DE   RecName: Full=Uncharacterized protein MT2059;
GN   OrderedLocusNames=MT2059;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
RN   [2]
RP   INDUCTION BY NITRIC OXIDE (NO) AND BY HYPOXIA, AND DORMANCY REGULON.
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12953092; DOI=10.1084/jem.20030205;
RA   Voskuil M.I., Schnappinger D., Visconti K.C., Harrell M.I., Dolganov G.M.,
RA   Sherman D.R., Schoolnik G.K.;
RT   "Inhibition of respiration by nitric oxide induces a Mycobacterium
RT   tuberculosis dormancy program.";
RL   J. Exp. Med. 198:705-713(2003).
CC   -!- INDUCTION: A member of the dormancy regulon. Induced in response to
CC       reduced oxygen tension (hypoxia) and low levels of nitric oxide (NO).
CC       {ECO:0000269|PubMed:12953092}.
CC   -!- SIMILARITY: Belongs to the methyltransferase superfamily.
CC       {ECO:0000305}.
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DR   EMBL; AE000516; AAK46336.1; -; Genomic_DNA.
DR   PIR; A70759; A70759.
DR   RefSeq; WP_003410049.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WJZ4; -.
DR   SMR; P9WJZ4; -.
DR   EnsemblBacteria; AAK46336; AAK46336; MT2059.
DR   KEGG; mtc:MT2059; -.
DR   PATRIC; fig|83331.31.peg.2216; -.
DR   HOGENOM; CLU_037990_14_1_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:InterPro.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR013216; Methyltransf_11.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   Pfam; PF08241; Methyltransf_11; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
PE   2: Evidence at transcript level;
FT   CHAIN           1..285
FT                   /note="Uncharacterized protein MT2059"
FT                   /id="PRO_0000427744"
SQ   SEQUENCE   285 AA;  31049 MW;  6590EBBA8C9E7842 CRC64;
     MVKRSRATRL SPSIWSGWES PQCRSIRARL LLPRGRSRPP NADCCWNQLA VTPDTRMPAS
     SAAGRDAAAY DAWYDSPTGR PILATEVAAL RPLIEVFAQP RLEIGVGTGR FADLLGVRFG
     LDPSRDALMF ARRRGVLVAN AVGEAVPFVS RHFGAVLMAF TLCFVTDPAA IFRETRRLLA
     DGGGLVIGFL PRGTPWADLY ALRAARGQPG YRDARFYTAA ELEQLLADSG FRVIARRCTL
     HQPPGLARYD IEAAHDGIQA GAGFVAISAV DQAHEPKDDH PLESE