ID   Y2003_STRP8             Reviewed;         286 AA.
AC   P67375; Q99Y04;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=DegV domain-containing protein spyM18_2003;
GN   OrderedLocusNames=spyM18_2003;
OS   Streptococcus pyogenes serotype M18 (strain MGAS8232).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=186103;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGAS8232;
RX   PubMed=11917108; DOI=10.1073/pnas.062526099;
RA   Smoot J.C., Barbian K.D., Van Gompel J.J., Smoot L.M., Chaussee M.S.,
RA   Sylva G.L., Sturdevant D.E., Ricklefs S.M., Porcella S.F., Parkins L.D.,
RA   Beres S.B., Campbell D.S., Smith T.M., Zhang Q., Kapur V., Daly J.A.,
RA   Veasy L.G., Musser J.M.;
RT   "Genome sequence and comparative microarray analysis of serotype M18 group
RT   A Streptococcus strains associated with acute rheumatic fever outbreaks.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:4668-4673(2002).
CC   -!- FUNCTION: May bind long-chain fatty acids, such as palmitate, and may
CC       play a role in lipid transport or fatty acid metabolism. {ECO:0000250}.
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DR   EMBL; AE009949; AAL98484.1; -; Genomic_DNA.
DR   RefSeq; WP_002982687.1; NC_003485.1.
DR   AlphaFoldDB; P67375; -.
DR   SMR; P67375; -.
DR   GeneID; 57853332; -.
DR   KEGG; spm:spyM18_2003; -.
DR   HOGENOM; CLU_048251_4_1_9; -.
DR   OMA; LWPASIH; -.
DR   GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.1180.10; -; 1.
DR   InterPro; IPR003797; DegV.
DR   InterPro; IPR043168; DegV_C.
DR   Pfam; PF02645; DegV; 1.
DR   TIGRFAMs; TIGR00762; DegV; 1.
DR   PROSITE; PS51482; DEGV; 1.
PE   3: Inferred from homology;
KW   Lipid-binding.
FT   CHAIN           1..286
FT                   /note="DegV domain-containing protein spyM18_2003"
FT                   /id="PRO_0000209815"
FT   DOMAIN          3..282
FT                   /note="DegV"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00815"
FT   BINDING         62
FT                   /ligand="hexadecanoate"
FT                   /ligand_id="ChEBI:CHEBI:7896"
FT                   /evidence="ECO:0000250|UniProtKB:Q9X1H9"
FT   BINDING         94
FT                   /ligand="hexadecanoate"
FT                   /ligand_id="ChEBI:CHEBI:7896"
FT                   /evidence="ECO:0000250|UniProtKB:Q9X1H9"
SQ   SEQUENCE   286 AA;  31380 MW;  F67C179B79AD62A5 CRC64;
     MTFTIMTDST ADLNQTWAED HDIVLIGLTI LCDGEVYETV GPNRISSDYL LKKMKAGSHP
     QTSQINVGEF EKVFREHARN NKALLYLAFS SVLSGTYQSA LMARDLVRED YPDAVIEIVD
     TLAAAGGEGY LTILAAEARD SGKNLLETKD IVEAVIPRLR TYFLVDDLFH LMRGGRLSKG
     SAFLGSLASI KPLLWIDEEG KLVPIAKIRG RQKAIKEMVA QVEKDIADST VIVSYTSDQG
     SAEKLREELL AHENISDVLM MPLGPVISAH VGPNTLAVFV IGQNSR