ID   Y2004_MYCTO             Reviewed;         498 AA.
AC   P9WLN2; L0T9W8; P0A5F9; Q10852;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 39.
DE   RecName: Full=Uncharacterized protein MT2060;
GN   OrderedLocusNames=MT2060;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
RN   [2]
RP   INDUCTION BY NITRIC OXIDE (NO) AND BY HYPOXIA, AND DORMANCY REGULON.
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12953092; DOI=10.1084/jem.20030205;
RA   Voskuil M.I., Schnappinger D., Visconti K.C., Harrell M.I., Dolganov G.M.,
RA   Sherman D.R., Schoolnik G.K.;
RT   "Inhibition of respiration by nitric oxide induces a Mycobacterium
RT   tuberculosis dormancy program.";
RL   J. Exp. Med. 198:705-713(2003).
CC   -!- SUBCELLULAR LOCATION: Secreted, cell wall {ECO:0000250}.
CC   -!- INDUCTION: A member of the dormancy regulon. Induced in response to
CC       reduced oxygen tension (hypoxia) and low levels of nitric oxide (NO).
CC       {ECO:0000269|PubMed:12953092}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAK46337.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE000516; AAK46337.1; ALT_INIT; Genomic_DNA.
DR   PIR; B70759; B70759.
DR   RefSeq; WP_003410057.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WLN2; -.
DR   EnsemblBacteria; AAK46337; AAK46337; MT2060.
DR   KEGG; mtc:MT2060; -.
DR   PATRIC; fig|83331.31.peg.2218; -.
DR   HOGENOM; CLU_026771_1_1_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Cell wall; Nucleotide-binding; Secreted.
FT   CHAIN           1..498
FT                   /note="Uncharacterized protein MT2060"
FT                   /id="PRO_0000427449"
FT   BINDING         329..336
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   498 AA;  54423 MW;  8FCE024F4004501E CRC64;
     MDSPTNDGTC DAHPVTDEPF IDVRETHTAV VVLAGDRAFK AKKPVVTDFC DFRTAEQRER
     ACIREFELNS RLAAQSYLGI AHLSDPSGGH AEPVVVMRRY RDKQRLASMV TAGLPVEGAL
     DAIAEVLARF HQRAQRNRCI DTQGEVGAVA RRWHENLAEL RHHADKVVSG DVIRRIEHMV
     DEFVSGREVL FAGRIKEGCI VDGHADLLAD DIFLVDGEPA LLDCLEFEDE LRYLDRIDDA
     AFLAMDLEFL GRKDLGDYFL AGYAVRSGDT APASLRDFYI AYRAVVRAKV ECVRFSQGKP
     EAAADAVRHL IIATQHLQHA TVRLALVGGN PGTGKSTLAR GVAELVGAQV ISTDDVRRRL
     RDCGVITGEP GVLDSGLYSR ANVVAVYQEA LRKARLLLGS GHSVILDGTW GDPQMRACAR
     RLAADTHSAI VEFRCSATVD VMADRIVARA GGNSDATAEI AAALAARQAD WDTGHRIDTA
     GPRERSVGQA YHIWRSAI