ID   CAPZA_KLULA             Reviewed;         262 AA.
AC   O74232; Q6CVA9;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2004, sequence version 2.
DT   25-MAY-2022, entry version 109.
DE   RecName: Full=F-actin-capping protein subunit alpha;
GN   Name=CAP1; OrderedLocusNames=KLLA0B13453g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 45-262.
RA   Banfield D.K.;
RT   "DNA sequence of the SFT1 gene from Kluyveromyces lactis.";
RL   Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: F-actin-capping proteins bind in a Ca(2+)-independent manner
CC       to the fast growing ends of actin filaments (barbed end) thereby
CC       blocking the exchange of subunits at these ends. Unlike other capping
CC       proteins (such as gelsolin and severin), these proteins do not sever
CC       actin filaments (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta subunit. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the F-actin-capping protein alpha subunit
CC       family. {ECO:0000305}.
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DR   EMBL; CR382122; CAH02523.1; -; Genomic_DNA.
DR   EMBL; AF072674; AAC24885.1; -; Genomic_DNA.
DR   RefSeq; XP_452130.1; XM_452130.1.
DR   AlphaFoldDB; O74232; -.
DR   SMR; O74232; -.
DR   STRING; 28985.XP_452130.1; -.
DR   EnsemblFungi; CAH02523; CAH02523; KLLA0_B13453g.
DR   GeneID; 2897530; -.
DR   KEGG; kla:KLLA0_B13453g; -.
DR   eggNOG; KOG0836; Eukaryota.
DR   HOGENOM; CLU_045161_3_0_1; -.
DR   InParanoid; O74232; -.
DR   OMA; HVHYYED; -.
DR   Proteomes; UP000000598; Chromosome B.
DR   GO; GO:0030479; C:actin cortical patch; IEA:EnsemblFungi.
DR   GO; GO:0005934; C:cellular bud tip; IEA:EnsemblFungi.
DR   GO; GO:0008290; C:F-actin capping protein complex; IEA:EnsemblFungi.
DR   GO; GO:0000131; C:incipient cellular bud site; IEA:EnsemblFungi.
DR   GO; GO:0051015; F:actin filament binding; IEA:EnsemblFungi.
DR   GO; GO:0051016; P:barbed-end actin filament capping; IEA:EnsemblFungi.
DR   Gene3D; 3.30.1140.60; -; 1.
DR   Gene3D; 3.90.1150.210; -; 1.
DR   InterPro; IPR002189; CapZ_alpha.
DR   InterPro; IPR037282; CapZ_alpha/beta.
DR   InterPro; IPR042276; CapZ_alpha/beta_2.
DR   InterPro; IPR042489; CapZ_alpha_1.
DR   InterPro; IPR017865; F-actin_cap_asu_CS.
DR   PANTHER; PTHR10653; PTHR10653; 1.
DR   Pfam; PF01267; F-actin_cap_A; 1.
DR   PRINTS; PR00191; FACTINCAPA.
DR   SUPFAM; SSF90096; SSF90096; 1.
DR   PROSITE; PS00748; F_ACTIN_CAPPING_A_1; 1.
DR   PROSITE; PS00749; F_ACTIN_CAPPING_A_2; 1.
PE   3: Inferred from homology;
KW   Actin capping; Actin-binding; Reference proteome.
FT   CHAIN           1..262
FT                   /note="F-actin-capping protein subunit alpha"
FT                   /id="PRO_0000208643"
FT   CONFLICT        116
FT                   /note="Y -> S (in Ref. 2; AAC24885)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        209..212
FT                   /note="Missing (in Ref. 2; AAC24885)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   262 AA;  29968 MW;  4D6914F684463513 CRC64;
     MSEFEKIVRD IVFDSPPEEI SLVYDNLQVL SDGQSKQQIA SIIQEFNEKH RVPAAKGEER
     YLVSEYNKSG SKYFDPVNKV LFAVDHITRE ASDIEEYTSE DATQVQSDLY DELSKYVSNF
     FPDTAVFNVF KIPESDQYAI IVVSNKKSLG DFWTGYWLSE YVYDVDGDTI SGEVSVDAHY
     FEDGNVRFKS TASLESAQTD SPIVSIKQFE NEFEKNLINK FQYMNETQFK GLRRRLPVTR
     AKINWGQGIG NYRLGRDAAQ GA