ID   Y2025_MYCTO             Reviewed;         332 AA.
AC   P9WGF4; F2GG63; L0T8K1; O53471; Q7D7L8;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 37.
DE   RecName: Full=Probable cation efflux system protein MT2084;
GN   OrderedLocusNames=MT2084;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the cation diffusion facilitator (CDF)
CC       transporter (TC 2.A.4) family. {ECO:0000305}.
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DR   EMBL; AE000516; AAK46363.1; -; Genomic_DNA.
DR   PIR; H70941; H70941.
DR   RefSeq; WP_003410146.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WGF4; -.
DR   SMR; P9WGF4; -.
DR   EnsemblBacteria; AAK46363; AAK46363; MT2084.
DR   KEGG; mtc:MT2084; -.
DR   PATRIC; fig|83331.31.peg.2248; -.
DR   HOGENOM; CLU_013430_3_1_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008324; F:cation transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1510.10; -; 1.
DR   Gene3D; 3.30.70.1350; -; 1.
DR   InterPro; IPR002524; Cation_efflux.
DR   InterPro; IPR027470; Cation_efflux_CTD.
DR   InterPro; IPR036837; Cation_efflux_CTD_sf.
DR   InterPro; IPR027469; Cation_efflux_TMD_sf.
DR   Pfam; PF01545; Cation_efflux; 1.
DR   Pfam; PF16916; ZT_dimer; 1.
DR   SUPFAM; SSF160240; SSF160240; 1.
DR   SUPFAM; SSF161111; SSF161111; 1.
DR   TIGRFAMs; TIGR01297; CDF; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Ion transport; Membrane; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..332
FT                   /note="Probable cation efflux system protein MT2084"
FT                   /id="PRO_0000428371"
FT   TRANSMEM        46..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        75..95
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        113..133
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        145..165
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        202..222
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   332 AA;  35207 MW;  164702355663C140 CRC64;
     MTHDHAHSRG VPAMIKEIFA PHSHDAADSV DDTLESTAAG IRTVKISLLV LGLTALIQIV
     IVVMSGSVAL AADTIHNFAD ALTAVPLWIA FALGAKPATR RYTYGFGRVE DLAGSFVVAM
     ITMSAIIAGY EAIARLIHPQ QIEHVGWVAL AGLVGFIGNE WVALYRIRVG HRIGSAALIA
     DGLHARTDGF TSLAVLCSAG GVALGFPLAD PIVGLLITAA ILAVLRTAAR DVFRRLLDGV
     DPAMVDAAEQ ALAARPGVQA VRSVRMRWIG HRLHADAELD VDPALDLAQA HRIAHDAEHE
     LTHTVPKLTT ALIHAYPAEH GSSIPDRGRT VE