ID   Y2025_MYCTU             Reviewed;         332 AA.
AC   P9WGF5; F2GG63; L0T8K1; O53471; Q7D7L8;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 44.
DE   RecName: Full=Probable cation efflux system protein Rv2025c;
GN   OrderedLocusNames=Rv2025c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   INDUCTION.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=17726022; DOI=10.1074/jbc.m703451200;
RA   Campbell D.R., Chapman K.E., Waldron K.J., Tottey S., Kendall S.,
RA   Cavallaro G., Andreini C., Hinds J., Stoker N.G., Robinson N.J.,
RA   Cavet J.S.;
RT   "Mycobacterial cells have dual nickel-cobalt sensors: sequence
RT   relationships and metal sites of metal-responsive repressors are not
RT   congruent.";
RL   J. Biol. Chem. 282:32298-32310(2007).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- INDUCTION: Transcription is repressed by KmtR. Induced by nickel and
CC       cobalt. {ECO:0000269|PubMed:17726022}.
CC   -!- SIMILARITY: Belongs to the cation diffusion facilitator (CDF)
CC       transporter (TC 2.A.4) family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP44798.1; -; Genomic_DNA.
DR   PIR; H70941; H70941.
DR   RefSeq; NP_216541.1; NC_000962.3.
DR   RefSeq; WP_003410146.1; NZ_NVQJ01000046.1.
DR   AlphaFoldDB; P9WGF5; -.
DR   SMR; P9WGF5; -.
DR   STRING; 83332.Rv2025c; -.
DR   PaxDb; P9WGF5; -.
DR   DNASU; 888782; -.
DR   GeneID; 888782; -.
DR   KEGG; mtu:Rv2025c; -.
DR   TubercuList; Rv2025c; -.
DR   eggNOG; COG0053; Bacteria.
DR   OMA; IEMHLIV; -.
DR   PhylomeDB; P9WGF5; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0015086; F:cadmium ion transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0008324; F:cation transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0015093; F:ferrous iron transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0015341; F:zinc efflux active transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0006876; P:cellular cadmium ion homeostasis; IBA:GO_Central.
DR   GO; GO:0006879; P:cellular iron ion homeostasis; IBA:GO_Central.
DR   GO; GO:0006882; P:cellular zinc ion homeostasis; IBA:GO_Central.
DR   Gene3D; 1.20.1510.10; -; 1.
DR   Gene3D; 3.30.70.1350; -; 1.
DR   InterPro; IPR002524; Cation_efflux.
DR   InterPro; IPR027470; Cation_efflux_CTD.
DR   InterPro; IPR036837; Cation_efflux_CTD_sf.
DR   InterPro; IPR027469; Cation_efflux_TMD_sf.
DR   Pfam; PF01545; Cation_efflux; 1.
DR   Pfam; PF16916; ZT_dimer; 1.
DR   SUPFAM; SSF160240; SSF160240; 1.
DR   SUPFAM; SSF161111; SSF161111; 1.
DR   TIGRFAMs; TIGR01297; CDF; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Ion transport; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..332
FT                   /note="Probable cation efflux system protein Rv2025c"
FT                   /id="PRO_0000419181"
FT   TRANSMEM        46..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        75..95
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        113..133
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        145..165
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        202..222
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   332 AA;  35207 MW;  164702355663C140 CRC64;
     MTHDHAHSRG VPAMIKEIFA PHSHDAADSV DDTLESTAAG IRTVKISLLV LGLTALIQIV
     IVVMSGSVAL AADTIHNFAD ALTAVPLWIA FALGAKPATR RYTYGFGRVE DLAGSFVVAM
     ITMSAIIAGY EAIARLIHPQ QIEHVGWVAL AGLVGFIGNE WVALYRIRVG HRIGSAALIA
     DGLHARTDGF TSLAVLCSAG GVALGFPLAD PIVGLLITAA ILAVLRTAAR DVFRRLLDGV
     DPAMVDAAEQ ALAARPGVQA VRSVRMRWIG HRLHADAELD VDPALDLAQA HRIAHDAEHE
     LTHTVPKLTT ALIHAYPAEH GSSIPDRGRT VE