Y2026_MYCTU
ID Y2026_MYCTU Reviewed; 294 AA.
AC P9WFD1; L0TBA6; O53472; Q7D7L7;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 03-AUG-2022, entry version 35.
DE RecName: Full=Universal stress protein Rv2026c;
DE Short=USP Rv2026c;
GN OrderedLocusNames=Rv2026c;
OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83332;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT genome sequence.";
RL Nature 393:537-544(1998).
RN [2]
RP IDENTIFICATION AS A DRUG TARGET [LARGE SCALE ANALYSIS].
RX PubMed=19099550; DOI=10.1186/1752-0509-2-109;
RA Raman K., Yeturu K., Chandra N.;
RT "targetTB: a target identification pipeline for Mycobacterium tuberculosis
RT through an interactome, reactome and genome-scale structural analysis.";
RL BMC Syst. Biol. 2:109-109(2008).
RN [3]
RP INDUCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=20541977; DOI=10.1016/j.tube.2010.03.013;
RA Hingley-Wilson S.M., Lougheed K.E., Ferguson K., Leiva S., Williams H.D.;
RT "Individual Mycobacterium tuberculosis universal stress protein homologues
RT are dispensable in vitro.";
RL Tuberculosis 90:236-244(2010).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT mass spectrometry.";
RL Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC -!- INDUCTION: Constitutively expressed during exponential phase, normoxic
CC and hypoxic stationary phase. {ECO:0000269|PubMed:20541977}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype under normal or hypoxic and
CC normoxic stationary phase growth. {ECO:0000269|PubMed:20541977}.
CC -!- MISCELLANEOUS: Was identified as a high-confidence drug target.
CC -!- SIMILARITY: Belongs to the universal stress protein A family.
CC {ECO:0000305}.
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DR EMBL; AL123456; CCP44799.1; -; Genomic_DNA.
DR PIR; A70942; A70942.
DR RefSeq; NP_216542.1; NC_000962.3.
DR RefSeq; WP_003410150.1; NZ_NVQJ01000046.1.
DR AlphaFoldDB; P9WFD1; -.
DR SMR; P9WFD1; -.
DR STRING; 83332.Rv2026c; -.
DR PaxDb; P9WFD1; -.
DR DNASU; 887460; -.
DR GeneID; 887460; -.
DR KEGG; mtu:Rv2026c; -.
DR TubercuList; Rv2026c; -.
DR eggNOG; COG0589; Bacteria.
DR OMA; HAWSDVG; -.
DR PhylomeDB; P9WFD1; -.
DR Proteomes; UP000001584; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.620; -; 2.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR006015; Universal_stress_UspA.
DR InterPro; IPR006016; UspA.
DR Pfam; PF00582; Usp; 2.
DR PRINTS; PR01438; UNVRSLSTRESS.
PE 1: Evidence at protein level;
KW ATP-binding; Nucleotide-binding; Reference proteome.
FT CHAIN 1..294
FT /note="Universal stress protein Rv2026c"
FT /id="PRO_0000396946"
FT BINDING 13
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="1"
FT /evidence="ECO:0000250|UniProtKB:P9WFD7"
FT BINDING 117..123
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="1"
FT /evidence="ECO:0000250|UniProtKB:P9WFD7"
FT BINDING 131..132
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="1"
FT /evidence="ECO:0000250|UniProtKB:P9WFD7"
FT BINDING 164
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /evidence="ECO:0000250|UniProtKB:P9WFD7"
FT BINDING 197
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /evidence="ECO:0000250|UniProtKB:P9WFD7"
FT BINDING 261..267
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /evidence="ECO:0000250|UniProtKB:P9WFD7"
FT BINDING 275..277
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /evidence="ECO:0000250|UniProtKB:P9WFD7"
SQ SEQUENCE 294 AA; 31456 MW; F0627782110F7142 CRC64;
MSAATAKYGI LVGVDGSAQS NAAVAWAARE AVMRQLPITL LHIVAPVVVG WPVGQLYANM
TEWQKDNAQQ VIEQAREALT NSLGESKPPQ VHTELVFSNV VPTLIDASQQ AWLMVVGSQG
MGALGRLLLG SISTALLHHA RCPVAIIHSG NGATPDSDAP VLVGIDGSPA SEAATALAFD
EASRRRVDLV ALHAWTDLGM FPVLGMDWRE REKREAEVLA ERLAGWQEQY PDVRVHRSLV
CDKPARWLLE HSEQAQLVVV GSHGRGGFSG MLLGSVSSAV AHSVRIPVIV VRPS
