ID   Y2028_MYCTO             Reviewed;         279 AA.
AC   P9WFD8; L0T9Z1; O53474; Q7D7L5;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 38.
DE   RecName: Full=Universal stress protein MT2087;
GN   OrderedLocusNames=MT2087;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
RN   [2]
RP   INDUCTION BY NITRIC OXIDE (NO) AND BY HYPOXIA, AND DORMANCY REGULON.
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12953092; DOI=10.1084/jem.20030205;
RA   Voskuil M.I., Schnappinger D., Visconti K.C., Harrell M.I., Dolganov G.M.,
RA   Sherman D.R., Schoolnik G.K.;
RT   "Inhibition of respiration by nitric oxide induces a Mycobacterium
RT   tuberculosis dormancy program.";
RL   J. Exp. Med. 198:705-713(2003).
CC   -!- INDUCTION: A member of the dormancy regulon. Induced in response to
CC       reduced oxygen tension (hypoxia) and low levels of nitric oxide (NO).
CC       {ECO:0000269|PubMed:12953092}.
CC   -!- SIMILARITY: Belongs to the universal stress protein A family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE000516; AAK46366.1; -; Genomic_DNA.
DR   PIR; C70942; C70942.
DR   RefSeq; WP_003410171.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WFD8; -.
DR   SMR; P9WFD8; -.
DR   EnsemblBacteria; AAK46366; AAK46366; MT2087.
DR   KEGG; mtc:MT2087; -.
DR   PATRIC; fig|83331.31.peg.2251; -.
DR   HOGENOM; CLU_049301_2_3_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   Gene3D; 3.40.50.620; -; 2.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   InterPro; IPR006015; Universal_stress_UspA.
DR   InterPro; IPR006016; UspA.
DR   Pfam; PF00582; Usp; 1.
DR   PRINTS; PR01438; UNVRSLSTRESS.
PE   2: Evidence at transcript level;
FT   CHAIN           1..279
FT                   /note="Universal stress protein MT2087"
FT                   /id="PRO_0000428556"
SQ   SEQUENCE   279 AA;  29442 MW;  52F240F9FE466AC9 CRC64;
     MNQSHKPPSI VVGIDGSKPA VQAALWAVDE AASRDIPLRL LYAIEPDDPG YAAHGAAARK
     LAAAENAVRY AFTAVEAADR PVKVEVEITQ ERPVTSLIRA SAAAALVCVG AIGVHHFRPE
     RVGSTAAALA LSAQCPVAIV RPHRVPIGRD AAWIVVEADG SSDIGVLLGA VMAEARLRDS
     PVRVVTCRQS GVGDTGDDVR ASLDRWLARW QPRYPDVRVQ SAAVHGELLD YLAGLGRSVH
     MVVLSASDQE HVEQLVGAPG NAVLQEAGCT LLVVGQQYL