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Y2028_MYCTU
ID   Y2028_MYCTU             Reviewed;         279 AA.
AC   P9WFD9; L0T9Z1; O53474; Q7D7L5;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 37.
DE   RecName: Full=Universal stress protein Rv2028c;
DE            Short=USP Rv2028c;
GN   OrderedLocusNames=Rv2028c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   INDUCTION BY HYPOXIA.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=11416222; DOI=10.1073/pnas.121172498;
RA   Sherman D.R., Voskuil M., Schnappinger D., Liao R., Harrell M.I.,
RA   Schoolnik G.K.;
RT   "Regulation of the Mycobacterium tuberculosis hypoxic response gene
RT   encoding alpha -crystallin.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:7534-7539(2001).
RN   [3]
RP   INDUCTION BY NITRIC OXIDE (NO) AND BY HYPOXIA, AND DORMANCY REGULON.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=12953092; DOI=10.1084/jem.20030205;
RA   Voskuil M.I., Schnappinger D., Visconti K.C., Harrell M.I., Dolganov G.M.,
RA   Sherman D.R., Schoolnik G.K.;
RT   "Inhibition of respiration by nitric oxide induces a Mycobacterium
RT   tuberculosis dormancy program.";
RL   J. Exp. Med. 198:705-713(2003).
RN   [4]
RP   INDUCTION BY CARBON MONOXIDE (CO), AND DORMANCY REGULON.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=18400743; DOI=10.1074/jbc.m802274200;
RA   Kumar A., Deshane J.S., Crossman D.K., Bolisetty S., Yan B.S., Kramnik I.,
RA   Agarwal A., Steyn A.J.;
RT   "Heme oxygenase-1-derived carbon monoxide induces the Mycobacterium
RT   tuberculosis dormancy regulon.";
RL   J. Biol. Chem. 283:18032-18039(2008).
RN   [5]
RP   DISRUPTION PHENOTYPE.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=20541977; DOI=10.1016/j.tube.2010.03.013;
RA   Hingley-Wilson S.M., Lougheed K.E., Ferguson K., Leiva S., Williams H.D.;
RT   "Individual Mycobacterium tuberculosis universal stress protein homologues
RT   are dispensable in vitro.";
RL   Tuberculosis 90:236-244(2010).
RN   [6]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- INDUCTION: A member of the dormancy regulon. Induced in response to
CC       reduced oxygen tension (hypoxia), low levels of nitric oxide (NO) and
CC       carbon monoxide (CO). It is hoped that this regulon will give insight
CC       into the latent, or dormant phase of infection.
CC       {ECO:0000269|PubMed:11416222, ECO:0000269|PubMed:12953092,
CC       ECO:0000269|PubMed:18400743}.
CC   -!- DISRUPTION PHENOTYPE: No visible phenotype under normal or hypoxic and
CC       normoxic stationary phase growth, nor in mouse- or human-derived
CC       macrophage cell lines. {ECO:0000269|PubMed:20541977}.
CC   -!- SIMILARITY: Belongs to the universal stress protein A family.
CC       {ECO:0000305}.
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DR   EMBL; AL123456; CCP44801.1; -; Genomic_DNA.
DR   PIR; C70942; C70942.
DR   RefSeq; NP_216544.1; NC_000962.3.
DR   RefSeq; WP_003410171.1; NZ_NVQJ01000046.1.
DR   AlphaFoldDB; P9WFD9; -.
DR   SMR; P9WFD9; -.
DR   STRING; 83332.Rv2028c; -.
DR   PaxDb; P9WFD9; -.
DR   DNASU; 888494; -.
DR   GeneID; 888494; -.
DR   KEGG; mtu:Rv2028c; -.
DR   TubercuList; Rv2028c; -.
DR   eggNOG; COG0589; Bacteria.
DR   OMA; WPSRYPD; -.
DR   PhylomeDB; P9WFD9; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0009274; C:peptidoglycan-based cell wall; HDA:MTBBASE.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   Gene3D; 3.40.50.620; -; 2.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   InterPro; IPR006015; Universal_stress_UspA.
DR   InterPro; IPR006016; UspA.
DR   Pfam; PF00582; Usp; 1.
DR   PRINTS; PR01438; UNVRSLSTRESS.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..279
FT                   /note="Universal stress protein Rv2028c"
FT                   /id="PRO_0000392627"
SQ   SEQUENCE   279 AA;  29442 MW;  52F240F9FE466AC9 CRC64;
     MNQSHKPPSI VVGIDGSKPA VQAALWAVDE AASRDIPLRL LYAIEPDDPG YAAHGAAARK
     LAAAENAVRY AFTAVEAADR PVKVEVEITQ ERPVTSLIRA SAAAALVCVG AIGVHHFRPE
     RVGSTAAALA LSAQCPVAIV RPHRVPIGRD AAWIVVEADG SSDIGVLLGA VMAEARLRDS
     PVRVVTCRQS GVGDTGDDVR ASLDRWLARW QPRYPDVRVQ SAAVHGELLD YLAGLGRSVH
     MVVLSASDQE HVEQLVGAPG NAVLQEAGCT LLVVGQQYL
 
 
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