ID   CAPZB_KLULA             Reviewed;         279 AA.
AC   Q6CPK5;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=F-actin-capping protein subunit beta;
GN   Name=CAP2; OrderedLocusNames=KLLA0E04114g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: F-actin-capping proteins bind in a Ca(2+)-independent manner
CC       to the fast growing ends of actin filaments (barbed end) thereby
CC       blocking the exchange of subunits at these ends. Unlike other capping
CC       proteins (such as gelsolin and severin), these proteins do not sever
CC       actin filaments (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta subunit. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus
CC       {ECO:0000250}. Note=Septum. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the F-actin-capping protein beta subunit family.
CC       {ECO:0000305}.
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DR   EMBL; CR382125; CAG99221.1; -; Genomic_DNA.
DR   RefSeq; XP_454134.1; XM_454134.1.
DR   AlphaFoldDB; Q6CPK5; -.
DR   SMR; Q6CPK5; -.
DR   STRING; 28985.XP_454134.1; -.
DR   EnsemblFungi; CAG99221; CAG99221; KLLA0_E04225g.
DR   GeneID; 2893811; -.
DR   KEGG; kla:KLLA0_E04225g; -.
DR   eggNOG; KOG3174; Eukaryota.
DR   HOGENOM; CLU_045864_1_1_1; -.
DR   InParanoid; Q6CPK5; -.
DR   OMA; MIEDMEI; -.
DR   Proteomes; UP000000598; Chromosome E.
DR   GO; GO:0099079; C:actin body; IEA:EnsemblFungi.
DR   GO; GO:0030479; C:actin cortical patch; IEA:EnsemblFungi.
DR   GO; GO:0008290; C:F-actin capping protein complex; IEA:EnsemblFungi.
DR   GO; GO:0043332; C:mating projection tip; IEA:EnsemblFungi.
DR   GO; GO:0031097; C:medial cortex; IEA:EnsemblFungi.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051015; F:actin filament binding; IEA:EnsemblFungi.
DR   GO; GO:0044396; P:actin cortical patch organization; IEA:EnsemblFungi.
DR   GO; GO:1904600; P:actin fusion focus assembly; IEA:EnsemblFungi.
DR   GO; GO:0051016; P:barbed-end actin filament capping; IEA:EnsemblFungi.
DR   GO; GO:1903475; P:mitotic actomyosin contractile ring assembly; IEA:EnsemblFungi.
DR   GO; GO:1902404; P:mitotic actomyosin contractile ring contraction; IEA:EnsemblFungi.
DR   GO; GO:0110055; P:negative regulation of actin filament annealing; IEA:EnsemblFungi.
DR   GO; GO:2000813; P:negative regulation of barbed-end actin filament capping; IEA:EnsemblFungi.
DR   GO; GO:0090339; P:negative regulation of formin-nucleated actin cable assembly; IEA:EnsemblFungi.
DR   GO; GO:2000601; P:positive regulation of Arp2/3 complex-mediated actin nucleation; IEA:EnsemblFungi.
DR   Gene3D; 1.20.58.570; -; 1.
DR   Gene3D; 3.90.1150.210; -; 1.
DR   InterPro; IPR037282; CapZ_alpha/beta.
DR   InterPro; IPR042276; CapZ_alpha/beta_2.
DR   InterPro; IPR001698; CAPZB.
DR   InterPro; IPR043175; CAPZB_N.
DR   InterPro; IPR019771; F-actin_capping_bsu_CS.
DR   PANTHER; PTHR10619; PTHR10619; 1.
DR   Pfam; PF01115; F_actin_cap_B; 1.
DR   PRINTS; PR00192; FACTINCAPB.
DR   SUPFAM; SSF90096; SSF90096; 1.
DR   PROSITE; PS00231; F_ACTIN_CAPPING_BETA; 1.
PE   3: Inferred from homology;
KW   Actin capping; Actin-binding; Cytoplasm; Cytoskeleton; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..279
FT                   /note="F-actin-capping protein subunit beta"
FT                   /id="PRO_0000256841"
SQ   SEQUENCE   279 AA;  32053 MW;  59AA6C2736F47FE4 CRC64;
     MSVDEKYDAA CELLYRLDPT KVKTHLQNLI ALEPEIAEGL LSSIDIPLTI KKDTDANNKE
     FLCCDYNRDI DSHRSPWSNQ YFPELSAEDL KESPFPSEPL RELEVACNNS FELYRDLYYE
     GGYTSTYLWD VDESTDFAGV ILFKKAESDD SKWDSIHVIS ATHDEEGMEV TYNVTTTVIL
     HLENLSKEQQ LSLSGNLTRE NSKTVKLQNV STVEQLVPAH SSSLGSMIED IESKLRSMLE
     IVYFEKTLDI YNVLRERNDD STKLQKEQHS ELIENFQKL