ID   Y2073_MYCTO             Reviewed;         249 AA.
AC   P9WGR2; L0T8J4; Q10681;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 34.
DE   RecName: Full=Uncharacterized oxidoreductase MT2133;
DE            EC=1.-.-.-;
GN   OrderedLocusNames=MT2133;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
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DR   EMBL; AE000516; AAK46413.1; -; Genomic_DNA.
DR   PIR; D70765; D70765.
DR   RefSeq; WP_003899156.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WGR2; -.
DR   SMR; P9WGR2; -.
DR   EnsemblBacteria; AAK46413; AAK46413; MT2133.
DR   KEGG; mtc:MT2133; -.
DR   PATRIC; fig|83331.31.peg.2301; -.
DR   HOGENOM; CLU_010194_2_1_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR   InterPro; IPR002347; SDR_fam.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase.
FT   CHAIN           1..249
FT                   /note="Uncharacterized oxidoreductase MT2133"
FT                   /id="PRO_0000428317"
FT   ACT_SITE        155
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10001"
FT   BINDING         11..34
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         142
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   249 AA;  25869 MW;  2E971711B37620A1 CRC64;
     MDDTGAAPVV IFGGRSQIGG ELARRLAAGA TMVLAARNAD QLADQAAALR AAGAIAVHTR
     EFDADDLAAH GPLVASLVAE HGPIGTAVLA FGILGDQARA ETDAAHAVAI VHTDYVAQVS
     LLTHLAAAMR TAGRGSLVVF SSVAGIRVRR ANYVYGSAKA GLDGFASGLA DALHGTGVRL
     LIARPGFVIG RMTEGMTPAP LSVTPERVAA ATACALVNGK RVVWIPWALR PMFVALRLLP
     RFVWRRMPR