Y2073_MYCTU
ID Y2073_MYCTU Reviewed; 249 AA.
AC P9WGR3; L0T8J4; Q10681;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 03-AUG-2022, entry version 36.
DE RecName: Full=Uncharacterized oxidoreductase Rv2073c;
DE EC=1.-.-.-;
GN OrderedLocusNames=Rv2073c; ORFNames=MTCY49.12c;
OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83332;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT genome sequence.";
RL Nature 393:537-544(1998).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT mass spectrometry.";
RL Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000305}.
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DR EMBL; AL123456; CCP44847.1; -; Genomic_DNA.
DR PIR; D70765; D70765.
DR RefSeq; NP_216589.1; NC_000962.3.
DR RefSeq; WP_003900457.1; NZ_NVQJ01000047.1.
DR AlphaFoldDB; P9WGR3; -.
DR SMR; P9WGR3; -.
DR STRING; 83332.Rv2073c; -.
DR PaxDb; P9WGR3; -.
DR DNASU; 887267; -.
DR GeneID; 45426050; -.
DR GeneID; 887267; -.
DR KEGG; mtu:Rv2073c; -.
DR TubercuList; Rv2073c; -.
DR eggNOG; COG0300; Bacteria.
DR OMA; VVHTDYV; -.
DR PhylomeDB; P9WGR3; -.
DR Proteomes; UP000001584; Chromosome.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR InterPro; IPR002347; SDR_fam.
DR Pfam; PF00106; adh_short; 1.
DR PRINTS; PR00081; GDHRDH.
DR SUPFAM; SSF51735; SSF51735; 1.
DR PROSITE; PS00061; ADH_SHORT; 1.
PE 1: Evidence at protein level;
KW Oxidoreductase; Reference proteome.
FT CHAIN 1..249
FT /note="Uncharacterized oxidoreductase Rv2073c"
FT /id="PRO_0000054864"
FT ACT_SITE 155
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10001"
FT BINDING 11..34
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000250"
FT BINDING 142
FT /ligand="substrate"
FT /evidence="ECO:0000250"
SQ SEQUENCE 249 AA; 25922 MW; 2E97170AA9C790A1 CRC64;
MDDTGAAPVV IFGGRSQIGG ELARRLAAGA TMVLAARNAD QLADQAAALR AAGAIAVHTR
EFDADDLAAH GPLVASLVAE HGPIGTAVLA FGILGDQARA ETDAAHAVAI VHTDYVAQVS
LLTHLAAAMR TAGRGSLVVF SSVAGIRVRR ANYVYGSAKA GLDGFASGLA DALHGTGVRL
LIARPGFVIG RMTEGMTPAP LSVTPERVAA ATARALVNGK RVVWIPWALR PMFVALRLLP
RFVWRRMPR