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Y2073_MYCTU
ID   Y2073_MYCTU             Reviewed;         249 AA.
AC   P9WGR3; L0T8J4; Q10681;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 36.
DE   RecName: Full=Uncharacterized oxidoreductase Rv2073c;
DE            EC=1.-.-.-;
GN   OrderedLocusNames=Rv2073c; ORFNames=MTCY49.12c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP44847.1; -; Genomic_DNA.
DR   PIR; D70765; D70765.
DR   RefSeq; NP_216589.1; NC_000962.3.
DR   RefSeq; WP_003900457.1; NZ_NVQJ01000047.1.
DR   AlphaFoldDB; P9WGR3; -.
DR   SMR; P9WGR3; -.
DR   STRING; 83332.Rv2073c; -.
DR   PaxDb; P9WGR3; -.
DR   DNASU; 887267; -.
DR   GeneID; 45426050; -.
DR   GeneID; 887267; -.
DR   KEGG; mtu:Rv2073c; -.
DR   TubercuList; Rv2073c; -.
DR   eggNOG; COG0300; Bacteria.
DR   OMA; VVHTDYV; -.
DR   PhylomeDB; P9WGR3; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR   InterPro; IPR002347; SDR_fam.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   1: Evidence at protein level;
KW   Oxidoreductase; Reference proteome.
FT   CHAIN           1..249
FT                   /note="Uncharacterized oxidoreductase Rv2073c"
FT                   /id="PRO_0000054864"
FT   ACT_SITE        155
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10001"
FT   BINDING         11..34
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         142
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   249 AA;  25922 MW;  2E97170AA9C790A1 CRC64;
     MDDTGAAPVV IFGGRSQIGG ELARRLAAGA TMVLAARNAD QLADQAAALR AAGAIAVHTR
     EFDADDLAAH GPLVASLVAE HGPIGTAVLA FGILGDQARA ETDAAHAVAI VHTDYVAQVS
     LLTHLAAAMR TAGRGSLVVF SSVAGIRVRR ANYVYGSAKA GLDGFASGLA DALHGTGVRL
     LIARPGFVIG RMTEGMTPAP LSVTPERVAA ATARALVNGK RVVWIPWALR PMFVALRLLP
     RFVWRRMPR
 
 
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