ID   Y2075_MYCTU             Reviewed;         487 AA.
AC   P9WLL5; L0TBE8; Q10683;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 30.
DE   RecName: Full=Uncharacterized protein Rv2075c;
GN   OrderedLocusNames=Rv2075c; ORFNames=MTCY49.14c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AL123456; CCP44849.1; -; Genomic_DNA.
DR   PIR; F70765; F70765.
DR   RefSeq; NP_216591.1; NC_000962.3.
DR   RefSeq; WP_003899158.1; NZ_NVQJ01000047.1.
DR   AlphaFoldDB; P9WLL5; -.
DR   STRING; 83332.Rv2075c; -.
DR   PaxDb; P9WLL5; -.
DR   DNASU; 888771; -.
DR   GeneID; 888771; -.
DR   KEGG; mtu:Rv2075c; -.
DR   TubercuList; Rv2075c; -.
DR   eggNOG; ENOG5032YHY; Bacteria.
DR   OMA; LGCTTEP; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008081; F:phosphoric diester hydrolase activity; IEA:InterPro.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR   Gene3D; 3.20.20.190; -; 1.
DR   InterPro; IPR016187; CTDL_fold.
DR   InterPro; IPR017946; PLC-like_Pdiesterase_TIM-brl.
DR   SUPFAM; SSF51695; SSF51695; 1.
DR   SUPFAM; SSF56436; SSF56436; 1.
PE   4: Predicted;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..487
FT                   /note="Uncharacterized protein Rv2075c"
FT                   /id="PRO_0000103946"
FT   TRANSMEM        10..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        45..65
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        439..459
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   487 AA;  51580 MW;  C063E0D112AC2154 CRC64;
     MPRARWLQSA ALMGALAVVL ITAAPVAADA YQVPAPPSPT ASCDVISPVA IPCVALGKFA
     DAVAAECRRV GVPDARCVLP LAHRVTQAAR DAYLQSWVHR TARFQDALQD PVPLRETQWL
     GTHNSFNSLS DSFTVSHADS NQQLSLAQQL DIDVRALELD LHYLPRLEGH GAPGVTVCHG
     LGPKNANLGC TVEPLLATVL PQIANWLNAP GHTEEVILLY LEDQLKNASA YESVVATLDQ
     VLRRADGTSL IYRPNPARRA TNGCVPLPLD VSREEIRASG ARAVLVGSCA PGWSAAVFDW
     SGVELESGSN SGYRPYPACD ATYGRGVYAW RLVRYYEDST LATALANPTR PPANPQALTP
     PKVPAMTDCG VNLFGFDQLL PEDGRIQASL WSWAPDEPRA GAGACALQGA DGRWVAASCG
     DPHPAACRDA AGRWTVTPAP VVFAGAALAC TAIGADFTLP RTGNQNARLH AVAGPAGGAW
     VHYLLPP