ID   Y2076_MYCPA             Reviewed;         310 AA.
AC   Q73Y81;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Putative S-adenosyl-L-methionine-dependent methyltransferase MAP_2076c;
DE            EC=2.1.1.-;
GN   OrderedLocusNames=MAP_2076c;
OS   Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10)
OS   (Mycobacterium paratuberculosis).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium avium complex (MAC).
OX   NCBI_TaxID=262316;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-968 / K-10;
RX   PubMed=16116077; DOI=10.1073/pnas.0505662102;
RA   Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N.,
RA   Kanjilal S., Kapur V.;
RT   "The complete genome sequence of Mycobacterium avium subspecies
RT   paratuberculosis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005).
CC   -!- FUNCTION: Exhibits S-adenosyl-L-methionine-dependent methyltransferase
CC       activity. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UPF0677 family. {ECO:0000305}.
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DR   EMBL; AE016958; AAS04393.1; -; Genomic_DNA.
DR   RefSeq; WP_003872446.1; NC_002944.2.
DR   AlphaFoldDB; Q73Y81; -.
DR   SMR; Q73Y81; -.
DR   STRING; 262316.MAP_2076c; -.
DR   EnsemblBacteria; AAS04393; AAS04393; MAP_2076c.
DR   KEGG; mpa:MAP_2076c; -.
DR   eggNOG; COG3315; Bacteria.
DR   HOGENOM; CLU_056160_2_1_11; -.
DR   OMA; DFFTRWV; -.
DR   Proteomes; UP000000580; Chromosome.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR011610; CHP00027_methylltransferase.
DR   InterPro; IPR007213; Ppm1/Ppm2/Tcmp.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   Pfam; PF04072; LCM; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   TIGRFAMs; TIGR00027; mthyl_TIGR00027; 1.
PE   3: Inferred from homology;
KW   Methyltransferase; Reference proteome; S-adenosyl-L-methionine;
KW   Transferase.
FT   CHAIN           1..310
FT                   /note="Putative S-adenosyl-L-methionine-dependent
FT                   methyltransferase MAP_2076c"
FT                   /id="PRO_0000361177"
FT   BINDING         131
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
FT   BINDING         160..161
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   310 AA;  33751 MW;  D1BC2CF9C401F980 CRC64;
     MPRTDNDTWD LSTSVGATAT MVAAARAIAT NADNPLIEDR FAEPLVRAVG VDFFTRWVTG
     DLVAADVDDH DSGWKLEHMP VAMAARTRFF DSFFQAATQA GIRQAVILAS GLDARAYRLA
     WPAGTTVFEI DQPQVIEFKT ATLAKLGATP QATLRTVAVD LRDDWPKALV EAGFDKGQPT
     AWIAEGLFGY LPPEAQDRLL DNITALSADG SRLACEAIPD MSEVDTEKAQ EMMRRATAKW
     REHGFDLEFG DLGYQGERND VAEYLDGLGW RSVGVPMSQL LADAGLEAIP QTNDSVSVAD
     TIYYSSVLAK