ID   Y2077_MYCTU             Reviewed;         323 AA.
AC   P9WLL1; L0TA38; P64933; Q10685;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 28.
DE   RecName: Full=Uncharacterized protein Rv2077c;
DE   Flags: Precursor;
GN   OrderedLocusNames=Rv2077c; ORFNames=MTCY49.16c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; AL123456; CCP44851.1; -; Genomic_DNA.
DR   PIR; H70765; H70765.
DR   RefSeq; NP_216593.1; NC_000962.3.
DR   RefSeq; WP_003899159.1; NZ_NVQJ01000047.1.
DR   AlphaFoldDB; P9WLL1; -.
DR   SMR; P9WLL1; -.
DR   STRING; 83332.Rv2077c; -.
DR   PaxDb; P9WLL1; -.
DR   DNASU; 887785; -.
DR   GeneID; 887785; -.
DR   KEGG; mtu:Rv2077c; -.
DR   TubercuList; Rv2077c; -.
DR   eggNOG; ENOG502ZB9M; Bacteria.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005829; C:cytosol; HDA:MTBBASE.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..45
FT                   /evidence="ECO:0000255"
FT   CHAIN           46..323
FT                   /note="Uncharacterized protein Rv2077c"
FT                   /id="PRO_0000014120"
FT   TRANSMEM        269..289
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        290..310
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          186..227
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   323 AA;  33321 MW;  4A7C6082E9E3CFB3 CRC64;
     MLATLSQIRA WSTEHLIDAA GYWTETADRW EDVFLQMRNQ AHAIAWNGAG GDGLRQRTRA
     DFSTVSGIAD QLRRAATIAR NGAGTIDAAQ RRVMYAVEDA QDAGFNVGED LSVTDTKTTQ
     PAAVQAARLA QAQALAGDIR LRVGQLVAAE NEVSGQLAAT TGDVGNVRFA GAPVVAHSAV
     QLVDFFKQDG PTPPPPGAPH PSGGADGPYS DPITSMMLPP AGTEAPVSDA TKRWVDNMVN
     ELAARPPDDP IAVEARRLAF QALHRPCNSA EWTAAVAGFA GSSAGVVGTA LAIPAGPADW
     ALLGAALLGV GGSGAAVVNC ATK